Sergolexole-maleate-生命科学试剂-MCE.pdfVIP

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Sergolexolemaleate

Cat.No.:HY-106324A

CASNo.:108674-87-9

分⼦式:C₃₀H₄₀N₂O₇

分⼦量:540.65

作⽤靶点:5-HTReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Sergolexolemaleate是⼀种强效的5-HT2受体拮抗剂。Sergolexolemaleate拮抗⾎清素增强的⾎⼩板聚集

[1][2]。

IC50Target5-HT2Receptor

REFERENCES

[1].CohenML,etal.5-Hydroxytryptamine2receptorantagonistactivityoftheacidmetabolite(1-isopropyldihydrolysergicacid)ofthe

ergolineester,sergolexole(LY281067).JPharmacolExpTher.1989Dec;251(3):1006-11.

[2].McBridePA,etal.Inhibitionofserotonin-amplifiedhumanplateletaggregationbyketanserin,ritanserin,andtheergoline5HT2receptor

antagonists-LY53857,sergolexole,andLY237733.LifeSci.1990;47(23):2089-95.

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