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Suvecaltamide(Standard)

Cat.No.:HY-101096R

CASNo.:953778-58-0

分⼦式:C₂₀H₂₃F₃N₂O₂

分⼦量:380.4

作⽤靶点:CalciumChannel;ReferenceStandards

作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling;

Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Suvecaltamide(Standard)是Suvecaltamide(HY-101096)的分析标准品。本产品⽤于研究及分析应⽤。

Suvecaltamide(MK-8998)是⼀种选择性T型钙离⼦通道抑制剂，具有⼝服有效性。Suvecaltamide在⾻髓瘤

细胞系中⽆细胞毒性，不影响Bortezomib(BTZ，HY-10227)的抗癌效果。Suvecaltamide在⼩⿏和⼤⿏模型

中逆转BTZ引起的周围神经病变(CIPN)，同时辅助抑制⾻髓瘤⽣长

IC50TargetT-typecalciumchannel[1].

REFERENCES

[1].CristinaMeregalli,etal.ReversalofBortezomib-InducedNeurotoxicitybySuvecaltamide,aSelectiveT-TypeCa-ChannelModulator,in

PreclinicalModels.Cancers(Basel).2021Oct7;13(19):5013.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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