SZL-P1-41-Standard-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

SZLP1-41(Standard)

Cat.No.:HY-100237R

CASNo.:222716-34-9

分⼦式:C₂₄H₂₄N₂O₃S

分⼦量:420.52

作⽤靶点:E1/E2/E3Enzyme;ReferenceStandards;Apoptosis

作⽤通路:MetabolicEnzyme/Protease;Others;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性SZLP1-41(Standard)是SZLP1-41(HY-100237)的分析标准品。本产品⽤于研究及分析应⽤。SZLP1-41是⼀

种特异的Skp2抑制剂，结合在Skp2的F-box域以防⽌与Skp1关联和Skp2SCF复合物形成。与Skp2缺乏

⼀样，SZLP1-41增加p27介导的凋亡/衰⽼，同时损害Akt驱动的糖酵解。具有抗肿瘤活性[1][2]。

IC50TargetSkp2[1]

REFERENCES

[1].ChanCHetal.PharmacologicalinactivationofSkp2SCFubiquitinligaserestrictscancerstemcelltraitsandcancerprogression.Cell.

2013Aug1;154(3):556-68.

[2].ChanCH,etal.Skp2:adreamtargetinthecomingageofcancertherapy.CellCycle.2014;13(5):679-80.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021-5895599