蛋白质翻译后修饰与靶向输送：从多肽链折叠到基因组学.pptx

Overviewoflastlecture?多肽链折叠为天然的三维构象:分子伴侣,蛋白质二硫键异构酶,肽-脯氨酰顺反异构酶?肽链一级结构的修饰、?空间结构的修饰等?靶向输送(至细胞特定部位)?翻译后修饰信号序列和信号肽(signalpeptide)核定位序列(NLS)(蛋白质翻译后修饰和靶向输送)

2.Mutationongenomics1.Genomicssequenceproject?Genomics（基因组学）?Proteome/Proteomics(蛋白质组)/(蛋白质组学)

S.cerevisiae(Yeast),C.elegans(线虫),Dmelanogaster(果蝇),Athaliana(拟南芥）,H.sapiens(Human,2001）,Daniorerio(Zebrafish),O.sativa(rice,2002),M.musculus(mouse,2002),S.scrofa(Pig,2005),R.norvegicus(Rat),shrimp,bamboon,chicken,cattle,wheat,maize,barley,soybean,cotton,parasite,pathogenicm