抗菌药物临床药理学.pptVIP

氟喹诺酮对于免疫正常动物模型肺炎链球菌感染的AUC/MIC与生存率之关系（W.A.Craig)（％)100802060400Mortality12.5510255010024HrAUC/MIC如何建立优化抗菌治疗治疗的PK/PD目标?1.MoutonJW,etal.Standardizationofpharmacokinetic/pharmacodynamic(PK/PD)terminologyforanti-infectivedrugs:anupdate.JAntimicrobChemother2005;55:601-7.2.Asín-PrietoE,etal.Applicationsofthepharmacokinetic/pharmacodynamic(PK/PD)analysisofantimicrobialagents.JInfectChemother.2015;21(5):319-329.3.张波,等.蒙特卡罗模拟在抗生素药动学和药效学中的应用.中国药学杂志.2008;43(4):241-244.图.与抗菌药物疗效相关的PK/PD指数13PK/PD指数(如,AUC/MIC)疗效2*PK/PD指数与治疗