医学论文：加味白头翁配方颗粒治疗湿热内蕴型溃疡性结肠炎的临床观察.docVIP

?????????????? 作者：黄平富，刘守志，魏宝强，武勇立【摘要】? 目的 观察加味白头翁配方颗粒治疗湿热内蕴型溃疡性结肠炎的临床疗效，比较其与传统汤药及西药柳氮磺吡啶的临床疗效。方法 96例溃疡性结肠炎患者随机分为加味白头翁配方颗粒组、加味白头翁汤汤药组及西药柳氮磺吡啶组，记录治疗前后患者临床症状、结肠黏膜的改善情况及不良反应。结果 加味白头翁配方颗粒和汤药治疗湿热内蕴型溃疡性结肠炎的疗效均优于西药柳氮磺吡啶片，差异有显著性(p0.05)。加味白头翁配方颗粒和传统汤剂的疗效相当(p0.05)。中药与西药的不良反应比较差异有非常显著性(p0.01)。结论 加味白头翁配方颗粒治疗湿热内蕴型溃疡性结肠炎安全有效。 【关键词】? 加味白头翁配方颗粒;溃疡性结肠炎;湿热内蕴型　　abstractobjective to investigate the clinical curative effect of jiawei baitouweng granule for damp-heat ulcerative colitis and compare the effect between the granule and sulfasalazine.methods the 96 patients were randomly divided into 3 groups of jiawei baitouweng granule group treated with the granule, traditional jiawei baitouweng decoction group with the decoction and western medicine sulfasalazine group with sulfasalazine tablet, 32 patients in each group. the difference of clinical symptoms, the variation of colonic mucosa and adverse reaction were observed before and after the treatment.result the curative effects of both the granule and the decoction were better than those of sulfasalazine for the ulcerative colitis (p0.05).the effects between the granule and the decoction were nearly same (p0.05).there was a very significant difference between traditional and western medicine group in adverse drug reactions (p0.01).conclusion jiawei baitouweng granule has a safe and obvious therapeutic efficacy on the damp-heat ulcerative colitis. 　　key words jiawei baitouweng granule; ulcerative colitis; damp-heat 　　溃疡性结肠炎(ulcerative colitis，uc)是一种迄今具体病因欠明的特发于大肠黏膜和黏膜下层的慢性非特异性炎症，以腹泻、腹痛、黏液脓血便和里急后重为主症。本病与中医的“大瘕泻”相似，归属于“泄泻”、“肠风”等范畴1。本研究旨在观察加味白头翁配方颗粒治疗湿热内蕴型溃疡性结肠炎的确切疗效。现报告如下。　　1 资料与方法　　1.1 一般资料 96例uc病例均为我院2008年8月—2010年6月门诊及住院患者，随机分为加味白头翁配方颗粒组(治疗组)、加味白头翁汤汤剂组(对照i组)、西药柳氮磺吡啶组(对照?组) 各32例。治疗组32例，男15例，女17例，年龄(36.9±14.9)岁，病程(4.4±2.8)年，病变位于直肠者10例，直、乙状结肠者18例，乙状结肠以上者4例;对照i组32例，男14例，女18例，年龄(36.4±15.4)岁，病程(4.5±3.6)年，病变位于直肠者11例，直、乙状结肠者18例，乙状结肠以上者3例;对照?组32例，男17例，女15例，年龄(38.6±17.5)岁，病程(5.1±3.9)年，病变位于直肠者9例，直、乙状结肠者20例，乙状结肠以上者3例。三组间的性别、年龄、病程、病变范围等差异均无显著性(p 0.0