医学论文：心肌活力饮对阿霉素所致大鼠心肌损伤的影响.docVIP

????????????作者：王仁平,张敏,吕志信,李清华,徐宏遵,刘红霞,黄瑞霞【摘要】? 目的 探讨心肌活力饮对阿霉素(adm) 诱导大鼠心肌损伤的保护作用和抗氧化作用。方法 选用adm 诱导大鼠心肌损伤模型。sd大鼠80 只,随机分为4个组, 每组20只,分别为正常对照组、模型对照组、心肌活力饮组(10 g原药材/kg)及阳性药黄芪生脉饮组(7 ml/kg)。除正常对照组外,其余各组大鼠分别腹腔注射adm(2.5 mg/kg),每周3次,共4周。到期测定血、心肌丙二醛(mda)含量和超氧化物歧化酶(sod)活性,并进行心肌病理检查。结果　心肌活力饮组及黄芪生脉饮组血液及心肌的mda 水平明显低于模型对照组,sod 水平则显著高于模型对照组,心肌病理计分下降。结论 心肌活力饮有抗氧化作用,对adm所引起的心肌损伤具有保护作用。 【关键词】? 心肌活力饮；阿霉素；丙二醛；超氧化物歧化酶；心肌损伤；大鼠　　abstract：objective to observe the protective and antioxidative effect of xinjihuoliyin on the myocardium injury induced by adriamycin (adm) in rats. methods 80 sd rats were randomly divided into four groups：normal group, control group, xinjihuoliyin group and positive control group (huangqishengmaiyin group). in control group, xinjihuoliyin group and huangqishengmaiyin group, adm was intraperitonial injected at a dose of 2.5 mg/kg, three times every week, for 4 weeks, while normal saline was intraperitonial injected at a dose of 3 ml/kg in normal group. in xinjihuoliyin group, xinjihuoliyin was intragastric administrated once a day at a dose of 10 g/kg. in huangqishengmaiyin group, huangqishengmaiyin was intragastric administrated once a day at a dose of 7 ml/kg and distilled water was given to other two groups. the activity of superoxide dismutase (sod) and the content of malondialdehyde (mda) of serum and myocardium were assayed. the myocardial pathomorphism was detected at the same time. results compared with the control group, mda of serum and myocardium was lower, and sod of serum and myocardium was higher in xinjihuoliyin and huangqishengmaiyin group. the scale of myocardial pathological damage in xinjihuoliyin and huangqishengmaiyin group was improved. conclusion xinjihuoliyin has protective effect and antioxidative effect on the myocardium injury induced by adriamycin in rats. 　　key words：xinjihuoliyin；adriamycin；mda；sod；myocardium injury；rat 　　阿霉素(adriamycin,adm)是蒽环类抗肿瘤药物,具有抗瘤谱广、作用强的特点,临床上广泛用于治疗各种恶性肿瘤。但由于adm具有明显的心肌毒性,而使其临床应用受到限制。心肌活力饮是石家庄长城中西医结合医院研制的治疗心肌病的