医学微生物学英文版课件_32.pptVIP

Hemorrhogic Fever Virus Dept. of microbiology and parasitology Hantaar Virus  (HEMORRHAGIC FEVER with renal syndrome virus ) Biological properties ssRNA with long, medium,short segments Antigens 6 serotypes (I- VI) Resistance: weak Epidemiology Natural host : rodents (deer mouse (Peromyscus maniculatus), cotton rat (Sigmodon hispidus), marsh rice rat (Oryzomys palustris) , white-footed mouse (Peromyscus leucopus), other carriers) Transmission : Droplet and rodent excreta spread Season and district Clinical syndromes Headache; Pink in face , neck Fever marked bleeding tendency Lower blood pressure Urine with Protein multi-organ failure Pathogenesis Viral direct damage Immunopathogenesis Laboratory diagnosis Cultivation: Vero-E6 cell and A549 cell Serological diagnosis: IgM/IgG indirect immunofluorescent assay ELISA-IgM Inactivated vaccine ? Xing Jiang Hemorrhogic Fever Virus Spherical, 80-120nm Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid (N), RNA polymerase (L) Envelope: 2 glycoproteins, G1 and G2, * * Hantaar Virus or HEMORRHAGIC FEVER with renal syndrome virus ( HFRS） Xing Jiang Hemorrhogic Fever Virus Spherical, 80-120nm Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid (N), RNA polymerase (L) Envelope: 2 glycoproteins, G1 and G2, Morphology Pathogenicity Clinical manifestations: 5 phases Fever phase Hypotension phase Auria phase Polyuria phase convalescent phase Vector and Host Animal Host Hyalomma asiaticum Season: April and May Inactivated vaccine * * *