WDR12基因单核苷酸多态性位点（rs6725887）与冠心病的关联研究及荟萃分析.docVIP

  WDR12 基因单核苷酸多态性位点 （rs6725887）与冠心病的关联研究及荟萃 分析# 5 10 15 20 25 30 35 40 黄毅1，刘艳红2，关艳丽2，王春明2，廉姜芳3，周建庆3，段世伟1** （1. 宁波大学医学院遗传学研究室，浙江 宁波 315211； 2. 浙江省宁波市鄞州人民医院心内科，浙江 宁波 315040； 3. 浙江省宁波市医疗中心李惠利医院心内科，浙江 宁波 315041） 摘要：目的 探讨 WD 重复蛋白 12（WDR12）基因单核苷酸多态性位点（Single Nucleotide Polymorphism，SNP，rs6725887）与冠心病患病风险的关联性。方法 对 273 名研究对象开 展了 rs6725887 位点的病例对照组遗传分析。此外，在涉及 81291 个体共 3 个人群对 rs6725887 位点与冠心病之间进行荟萃分析。结果 WDR12 基因的 rs6725887 多态性在冠心病和对照组 分布无统计学差异（P 0.05）。荟萃分析证明 rs6725887 多态性与欧洲和南亚人群冠心病 患病风险显著相关（P 0.0001，OR = 1.14，95% CI = 1.11 - 1.18）。结论 WDR12 基因 rs6725887 多态性与中国浙东人群冠心病患病风险性没有关联性。然而，荟萃分析显示 rs6725887 多态性显著增加欧洲和南亚人群中冠心病的患病风险。 关键词：冠心病；WD 重复蛋白 12；单核苷酸基因多态性；荟萃分析 中图分类号：R394.3 No association between WD repeat protein 12 gene variant (rs6725887) and coronary heart disease in Han Chinese HUANG Yi1, LIU Yanhong2, GUAN Yanli2, WANG Chunming2, LIAN Jiangfang3, ZHOU Jianqing3, DUAN Shiwei1 (1. Genetics laboratory,School of Medicine, Ningbo University, ZheJiang NingBo 315211; 2. Ningbo Yinzhou People’s Hospital, Ningbo University, ZheJiang NingBo 315040; 3. Ningbo Medical Center, Lihuili hospital, Ningbo University, ZheJiang NingBo 315041) Abstract: The goal of our study is to evaluate the contribution of rs6725887 of WD repeat protein 12 (WDR12) gene to the risk of coronary heart disease (CHD) in Han Chinese. We recruited 163 angiography-proven CHD patients and 113 angiography-normal controls originated from Ningbo in the Eastern China, and performed a case-control association study between rs6725887 and the risk of CHD. We were unable to find the association of rs6725887 with CHD in Han Chinese (P 0.05). A further meta-analysis showed that rs6725887 was significantly associated with an increasing risk of CHD (P 0.0001, OR = 1.14, 95% CI = 1.11 - 1.18), especially in Europeans and South Asians. Our case-control study could not identify a significant association of rs6725887 with the risk of CHD in Han Chinese. Meta-analysis has established rs6725887 as a risk factor of CHD in South