金欣口服液不同极性部位的抗炎、祛痰和解热实验研究.docVIP

  金欣口服液不同极性部位的抗炎、祛痰和解 热实验研究# 单进军，俞晶华，悉昕平，杜丽娜，徐建亚，汪受传** 5 10 （南京中医药大学第一临床医学院，南京 210046） 摘要：目的 研究金欣口服液不同极性部位的抗炎、祛痰和解热作用，筛选其治疗病毒性肺 炎的药效部位。方法 分别采用二甲苯致小鼠耳廓肿胀法、大鼠毛细管法排痰量和干酵母致 热大鼠模型考察金欣口服液及其不同极性部位（石油醚、乙酸乙酯、正丁醇和水）的抗炎、 祛痰和解热作用。结果 与空白对照组比较，乙酸乙酯部位（P0.05）和正丁醇部位（P0.01） 均有明显抑制二甲苯所致小鼠耳廓肿胀的作用；乙酸乙酯部位和正丁醇部位（P0.01）均能 显著增加大鼠毛细管排痰量；正丁醇部位对干酵母所致发热大鼠给药后 1h，2h，3h，4h， 5h 均有显著降热作用（P0.05 或 P0.01）。结论 乙酸乙酯部位和正丁醇部位是金欣口服液 治疗病毒性肺炎的主要药效部位。 关键词：金欣口服液；药效部位；抗炎；祛痰；解热 15 Anti-inframmatory, expectorant and antipyretic effects of different polar fractions from Jinxin Oral Liquid SHAN Jinjun, YU Jinghua, XI Xinping, DU Lina, XU Jianya, WANG Shouchuan (The First Medicine College, Nanjing University of Chinese Medicine, NanJing 210046) 20 25 30 35 40 Abstract: OBJECTIVE To evaluate anti-inframmatory, expectorant and antipyretic effects of different polar fractions from Jinxin Oral Liquid (JOL), and then screen the effective fractions treated viral pneumonia. METHODS xylene-induced auricular swelling in mice, measuring sputum capacity with capillary in rat and dried yeast suspension induced pyretogenesis in rat was respectively used to investigate anti-inframmatory, expectorant and antipyretic effects of JOL and its different fractions such as petroleum ether, ethyl acetate, n-butyl alcohol and water extracts. RESULTS Compared with the blank control group, ethyl acetate and n-butyl alcohol extracts significantly inhibited xylene-induced auricular swelling in mouse (P0.05 or P0.01), and also increased significantly sputum capacity in rats (P0.01). n-butyl alcohol extracts reduced significantly the fever induced by dried yeast suspension in rats (P0.05 or P0.01). CONCLUSION Ethyl acetate exract and n-butyl alcohol exract are the effective fractions of JOL treated viral pneumonia. Keywords: Jinxin Oral Liquid; effective fraction; anti-inframmatory; expectorant; antipyretic 0 引言 金欣口服液（原名清肺口服液）是由麻黄、黄芩、虎杖、杏仁、葶苈子等药物组成，根 据儿科用药特殊性研制而成的中药 6.1 类新药（已完成临床研究），具有宣肺开闭、清热解 毒、化痰止咳之功效。临床和实验研究均证实金欣口服液治疗小儿病毒性肺炎疗效肯定[1-2]。 本