磁敏感成像对SPIO定量测量的体外研究.docVIP

  磁敏感成像对 SPIO 定量测量的体外研究# 陈唯唯1，熊伟1，穆可涛1，余道武2，朱文珍1** （1. 华中科技大学同济医学院附属同济医院放射科，武汉，430030； 5 10 15 20 25 30 35 40 2. 华中科技大学同济医学院附属同济医院器官移植研究所，武汉，430030） 摘要：目的：比较幅度图、相位图及 SWI 图对于 SPIO 检测的敏感性及定量的准确性。方法： 采用 3.0T MR 扫描仪对不同浓度梯度（0.1, 0.075, 0.05,0.025,0.0125 mgFe/ml）SPIO 进行 eSWAN 序列扫描，在工作站重建幅度图，相位图及 SWI 图，计算各自的 CNR 并进行标准 化。将标准化 CNR 与已知的 SPIO 浓度进行相关分析，及直线曲线拟合，比较其最优的拟 合曲线。结果：随着 SPIO 浓度的增加，SWI 和幅度图上的信号强度呈下降趋势，phase 上 呈现混杂信号。SWI 图和幅度图的标准化 CNR 与 SPIO 浓度均有显著的相关性，且 SWI 图 的相关性更高（spearman correlation ，SWI：ρ =1.0，幅度图：ρ =0.943），而相位图无明 显相关性（spearman correlation ρ =-0.143）。SWI 图对于低浓度 SPIO（0.1mgFe/ml）的敏 感性较幅度图更高，且对不同 SPIO 浓度的鉴别能力更强。在较高浓度时（≥0.1mgFe/ml）, 无论 SWI 图或者幅度图标准化 CNR 的差别均明显减小。最佳拟合曲线比较显示 SWI 图对 SPIO 浓度的定量检测较之幅度图更为准确。结论：SWI 图较幅度图及相位图对 SPIO 的检 测有更高的敏感性和定量的准确性。 关键词：磁敏感成像；超顺磁性氧化铁；定量测量；准确性；体外实验 中图分类号：R445.2 Susceptibility weighted imaging on the quantitative measurement of SPIO in vitro. CHEN Weiwei1, XIONG Wei1, MU Ketao1, YU Daowu2, ZHU Wenzhen1 (1. Radiology Department,Tongji Hospital,Tongji Medical college,Huazhong University of Science Technology,Wuhan,430030; 2. Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College, Huazhong University of Science Techonology, Wuhan, 430030) Abstract: Objective: To compare the sensitivity and accuracy in the detection of SPIO between magnitude images, phase images and suscepitibility weighted images(SWI).Method: The phantom of different concentration of SPIO（0.1, 0.075, 0.05,0.025,0.0125 mgFe/ml）was scanned eSWAN sequence on a 3T MRI. Magnitude images, phase images and SWI were generated on workstation. Their contrast noise ratios(CNR)were calculated and standardized. Correlation and curve fitting were analyzed between standard CNR and the concentration of SPIO for each images.Results:With the concentration of SPIO increasing, signal intensity(SI) decreases on SWI and magnitude images, while SI appears heterogeneous on phase images. Significant correlation was found between standard CNR and concentration of SPIO on both SWI