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International Journal of Pharmaceutics 385 (2010) 113–142 Contents lists available at ScienceDirect International Journal of Pharmaceutics j o u rn al h omepage: w w w. elsev /locate/ijpharm Pharmaceutical Nanotechnology Polymer-based nanocapsules for drug delivery C.E. Mora-Huertas a,b , H. Fessi a,b,∗ , A. Elaissari a,b,∗ a Université de Lyon, F-69622, Lyon, France b Université Lyon 1, CNRS, UMR 5007, Laboratoire d’Automatique et de Génie des Procédés, LAGEP-CPE-308G, 43 bd. du 11 Nov.1918, F-69622, Villeurbanne, France a r t i c l e i n f o a b s t r a c t Article history: A review of the state of knowledge on nanocapsules prepared from preformed polymers as active Received 22 July 2009 substances carriers is presented. This entails a general review of the different preparation methods: Received in revised form 1 October 2009 nanoprecipitation, emulsion–diffusion, double emulsification, emulsion-coacervation, polymer-coating Accepted 3 October 2009 and layer-by-layer, from the point of view of the methodological and mechanistic aspects involved, Available online 13 October 2009 encapsulation of the active substance and the raw materials used. Similarly, a comparative analysis is