导电高聚物在生物传感器中的应用.pdfVIP

导电高聚物在生物传感器中的应用/乐 知等 ·33 · 导电高聚物在生物传感器中的应用* 1 1 1,2 乐 知 ，吴仲岿 ，陈 红 （1 武汉理工大学材料科学与工程学院；2 武汉理工大学生物材料与工程研究中心，武汉 430070） 摘要 综述了导电高聚物用于生物传感器的研究进展。在简要介绍生物传感器原理、特点的基础上，概要回顾了生物传 感器中运用导电高聚物如聚苯胺（PANI ）、聚噻吩(PTH)和聚吡咯(PPy)进行电极化学修饰的基本方法，着重综述了近年来 在荧光生物传感器中导电高分子如聚苯撑乙烯（PPV ）、聚芴（PF ）等水溶性衍生物应用的研究进展，分别对基于水溶性共 轭高分子荧光淬灭及荧光共振能量转移(FRET)生物传感器等提高灵敏度和选择性的原理、特点和具体实例进行了介绍，并 对导电高聚物生物传感器的研究做了展望。 关键词 生物传感器 导电高聚物 光诱导电荷转移 荧光共振能量转移 Applications of Conducting Polymers in Biosensors 1 1 1,2 YUE Zhi ，WU Zhongkui ，CHEN Hong (1 School of Materials Science and Engineering, Wuhan University of Technology; 2 Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan 430070) Abstract In this review, some new applications of conducting polymers in biosensors are briefly introduced. Chemical modifications of electrodes by conducting polymers such as polyaniline(PANI), polythiophene(PTH) and polypyrrole(PPy) are described based on a brief introduction to the principles and characters of biosensors. The progress in the applications of water-soluble derivatives of some conducting polymers such as poly(phenylene vinylene)(PPV) and polyfluorene(PF) in fluorescence biosensor is presented. Some new developments in sensitivity and selectivity of biosensors based on the principles of fluorescence quenching and fluorescence resonance energy transfer (FRET) are summarized. The further research directions of conducting polymer biosensors are also discussed in this article. Key words biosensor , conducting polymer, photoinduced electron transfer, fluorescence resonance energy