超声瞬时弹性成像的系统设计和实验研究.pdfVIP

Vol. 4 No.1/ Jan.Vol. 4 No.1/ Jan. 010010 超声瞬时弹性成像的系统 设计和实验研究 The system design and experiment study for ultrasound transient elastography 李彦明　姚慧　刘石壮　熊昊　郑海荣 摘 要 超声弹性成像是一种瞬时成像技术，在临床应用组织参数评估方面有广泛的应用。我们设计了一种基于瞬时弹性 成像的非侵入式的实时获取组织硬度信息的系统。系统的性能主要取决于AD转换之前的电路设计，尤其是低噪声前置放大 部分对噪声非常敏感。如何提高信噪比是系统的关键。文中给出了一种时间增益补偿的例子。通过体模和活体实验，对返 回的射频信号进行互相关和微分运算，从而获得组织的位移信息，进而从应变图中获得组织的杨氏模量。文中讨论了信噪 比对应变质量的影响。最后提出了一种基于AD9272的优化方法。 关键词 信噪比；时间增益补偿；弹性成像；换能器；杨氏模量 ABSTRACT Elastography is an emerging ultrasonic imaging technique; it has a broad clinical application for tissue parameter estimation. We designed a real-time system to measure tissue stiffness information non-invasively based on transient elastography. The system performance mainly depends on the circuit design before the Analog-to-Digital Converter (A/D), especially the preamplifier part which is very sensitive to the noise. How to improve the signal-to-noise (SNR) is the key factor for the system design. In this paper, the Time Gain Control (TGC) design is discussed as an example of the circuit design. Displacement tracking algorithm based on correlation techniques and differentiation are applied to Radio frequency (RF) signals from tissues mimicking phantom and in vivo experiments; the young’s modulus of the tissue is estimated from the strain images. The influences of the SNR to the strain image quality are discussed. At the end, an improvement based on the AD is proposed. KEYWORDS　SNR;TGC;elastography;LNA; transducer;young’s modulus 1 Introduction lastography is an emerging ultrasonic imaging stricter requirement on the preamplifier circuit design, Etechnique since Profes