胃食管反流性咳嗽的发病机制及治疗.pdfVIP

．综述． 胃食管反流性咳嗽的发病机制及诊疗 王宇 余莉邱忠民 【摘要】胃食管反流性咳嗽为胃食管反流病的一种特殊类型。是慢性咳嗽常见病因之一。与典型 胃食管反流病相比，胃食管反流性咳嗽在发病机制、诊疗方面有其特点。胃食管反流性咳嗽的发病机制 可能是高位反流、低位反流和气道高敏感性等多因素共同作用的结果。诊断需结合临床表现和辅助检查 建立，多通道食管腔内阻抗联合pH监测可以区分酸与非酸性反流。是有前景的诊断技术，抗反流药物治 疗是目前胃食管反流性咳嗽的主要治疗方法。 【关键词】胃食管反流；咳嗽；机制；诊断；治疗 WANG andtreatmentof reflux-relatedchronic h，yU“， Pathogenesis，diagnosisgastroesophageal cough Medical·Tot,Igji QfU ofRespiratoryMedicine，TongjiHospital．Schoolof Zhong—min．Department 200065，China University。Shanghai reflux of refluxdisease，is [Abstract]Gastroesophagealcough，aspecialtype gastroesophageal reflux consideredasoneofthemostcommoncausesofchronic cough cough．However，gastroesophageal withdistalor hasitsowncharacteristicsin andtreatment．Ithasassociated pathogenesis，diagnosis refluxand of reflux is proximal airwayhypersensitivity．Thediagnosisgastroesophagealcoughdependent thecombinationofclinical and intraluminal upon presentationlaboratoryinvestigations．Muhichannel whichisabletO and isa recently pHmonitoringpromisingtechniquedeveloped esophagealimpedance detectbothacidandnon-acid with isstillthemain reflux．Currently，anti—refluxtherapydrugs approach for reflux gastroesophagealcough． reflux [KeyWords]Gastroesophagealdisease；Cough；Pathogenesis；Diagnosis；Treatment reflux的结构和功能异常而反流至咽喉或误吸入肺，刺