CTHRC1与肿瘤关系的研究进展.pdfVIP

第22卷 第8期 生命科学 Vol. 22, No. 8 2010年8月 Chinese Bulletin of Life Sciences Aug., 2010 文章编号 ：1004-0374(2010)08-0797-04 CTHRC1 与肿瘤关系的研究进展 王　萍1,2，房静远1* (1 上海交通大学医学院附属仁济医院上海市消化疾病研究所，上海 200001； 2上海交通大学医学院附属第九人民医院消化内科，上海 200011) 摘　要：胶原三股螺旋重复蛋白1 基因是从大鼠正常动脉和受损动脉中筛选出的差异表达基因，其通过 TGF-β 和Wnt/PCP 通路发挥作用，使胶原生成减少，促进细胞迁移。在多种肿瘤中发现CTHRC1 异常 表达，并与肿瘤转移相关。该文就 CT HRC 1 与肿瘤的关系作一综述。 关键词：胶原三股螺旋重复蛋白1；肿瘤；TGF- β 通路；W nt/PCP 通路 中图分类号：R730.23　　文献标识码：A The relationship between CTHRC1 and cancer 1,2 1 WANG Ping , FANG Jing-yuan * (1 Shanghai Institute of Digestive Diseases, Renji Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China; 2 Department of Gastroenterology, No.9 Peoples’ Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China) Abstract: CTHRC1 gene was first found in a screening for differentially expressed sequences in balloon-injured versus normal rat arteries，which is involved in TGF-β signaling and Wnt signaling，limiting collagen matrix deposition and promoting cell migration. Aberrant expression of CTHRC1 is widely present in human solid cancers and seems to be associated with cancer tissue invasion and metastasis. In this article, authors reviewed the relationship between CTHRC1 and cancer. Keywords: collagen triple helix repeat containing 1; cancer; TGF-β signaling; Wnt/PCP signaling 胶原三股螺旋重复蛋白1(collagen triple helix re- 性[3]，说明CTHRC1 在进化上高度保守。CTHRC1 peat containing 1, CTHRC1)基因是动脉损伤过程中筛 蛋白包含具有细胞外分泌功能的N-末端信号肽以及 选出的一种过表达基因，CTHRC1 可减少胶原沉积， 由36个氨基酸组成的胶原