黄龙口服液治疗小鼠柯萨奇病毒性心肌炎的疗效观察.pdfVIP

2·46 · Ch in J Pediatr, July 1996, V o l 34, N o. 4 黄龙口服液治疗小鼠柯萨奇B 3 病毒性心肌炎的疗效观察 黄星原　江钟炎　麦根荣　赵利淦 　　摘要　为探讨“黄龙”口服液治疗病毒性心肌炎的疗效, 对 32 只小鼠柯萨奇B 3 病毒性心肌炎进 行实验性治疗。结果表明: 治疗组 32 只, 死亡 16 只, 病死率为 50% ; 对照组 40 只, 死亡 36 只, 病死率 ( 2 ) ( 为 90% = 14 18, 0 01 。治疗组平均死亡时间为 22 ±4 天, 对照组为 5 ±2 天 = 23 02, P t P 0 01) 。电镜观察结果发现治疗组心肌细胞变性、溶解和坏死改变较对照组轻, 存活时间长者的心 肌细胞的形态和结构更接近正常。提示, “黄龙”口服液对小鼠实验性病毒性心肌炎有显著疗效。 ( ) 关键词　心肌炎　　柯萨奇病毒B 组　　复方 中药 A study on therapeutic effectiveness of Huanglong solution on m ice with m yocarditis induced by cox- sack ie v irus B3 　H uang X ingy uan , J iang Z hongy an , M ai Genrong , et al. D ep artm ent of P ed i atrics, F irst T each ing H osp ital , H ubei M ed ical U niversity , W uhan 430060 Abstract　To test po ssible therapeutic effect of H uanglong so lution on viral m yocarditis, w e app lied it to 32 m ice w ith m yocarditis induced by coxsack ie virus B . T he results show ed that it could 3 significantly reduce the mo rtality (2 = 14. 18, P 0 01) and p ro long the average survival tim e of ( ) m ice w ith m yocarditis t= 23 02, P 0 01 . T he results from electronic m icro scop ic study show ed that H uanglong so lution could m aintain intact structure of m yocardial cells, elim inate virus and disad vantageous p roducts of m e