抗体介导慢性排斥反应中内皮细胞基因变化及分子机制.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(1): 123– 127 DOI: 10.11844/cj cb.2014.01.0290 抗体介导的慢性排斥反应中内皮细胞基因的 变化及分子机制 李 珅1 董 杰2 伍会健1﹡ 1 2 ( 大连理工大学生命科学与技术学院, 大连116024; 东北财经大学职业技术学院, 大连11602 1) 摘要 目前, 抗体介导的慢性肾移植排斥反应难以预测, 尚无有效的治疗方法。研究表明, 通 过对内皮细胞相关基因的分析, 可以提高抗体介导的慢性肾移植排斥反应术前及术后的诊断特异 性。该病的发病机制主要包括四个方面: (1)血小板在内皮细胞附近聚集凝固能力增强; (2) 内皮细 γ γ 胞趋化炎性细胞作用增强; (3)干扰素- (IFN- )杀伤作用增强; (4) 内皮修复再生能力降低。基因分析 结合抗体分析有助于深化理解抗体介导的肾移植排斥反应的发病机理、提高诊疗效果、为新药开 发提供新靶点, 使肾移植成功率大幅提高成为可能。该篇综述将就上述内容作一介绍。 关键词 抗体介导的排斥反应; 内皮细胞; 基因聚类分析 Endothelial Gene Expression and Molecule Mechanism in Chronic Antibody-Mediated Rejection of Renal Allograft 1 2 1* Li Shen , Dong Jie , Wu Huijian 1 2 ( School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China; Vocational Technology College Dongbei University of Finance and Economics, Dalian 116021, China) Abstract Currently, antibody-mediated rejection of renal allograft is highly unpredictable and lack of ef- fective treatments. A number of studies show that the preoperative and postoperative diagnosises of renal allograft are improved by the analysis of endothelial cell associated genes. The pathogenesis of this disease mainly includes four aspects: ( 1) The aggregation and coagulation ability of platelet increases near in endothelial cells; (2) The chemotaxis of inflammatory cells by endothelial cells increases; (