羊水来源干细胞骨向分化的研究进展.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2013, 35(8): 1221–1224 DOI: 10.11844/cjcb.2013.08.0103 羊水来源干细胞骨向分化的研究进展 1 1* 2* 司家文 沈国芳 郭礼和 1 ( 上海交通大学医学院附属第九人民医院口腔颅颌面科, 上海 200011; 2 中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 上海 200031) 摘要 2007年, de Coppi等在Nature Biotechnology杂志上报道了从羊水中获取具有多向分化潜能 的干细胞亚群的实验结果, 证明羊水细胞除了用于产前诊断之外, 还可成为极具前景的干细胞源。羊 水来源干细胞, 作为一种特殊来源的干细胞类型, 具有独特的细胞生物学特性和广泛的多向分化潜力。 随着研究的深入, 羊水来源干细胞在骨组织再生领域逐渐突显其潜在的研究和应用价值, 有必要就近 年来羊水来源干细胞特性及其成骨分化的研究进展进行综述, 从而为相关领域的研究提供参考。 关键词 羊水; 干细胞; 骨向分化; 骨组织工程 Research Progress on Osteogenic Differentiation of Amniotic Fluid-derived Stem Cells 1 1*, Guo Lihe2 * Si Jiawen , Shen Guofang 1 ( Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 2 Shanghai 200011, China; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China) Abstract In 2007, de Coppi et al reported the isolation of a stem-cell subpopulation with multi-differentiation potential from amniotic fluids in the journal of Nature Biotechnology, which prove that amniotic fluids may become a promising source of stem cells, in addition to specimens for prenatal diagnosis. Amniotic fluid-derived stem cell, a special type of stem cells, has been shown to possess unique biological characteristics and a comprehensive multi-differentiation potential. With further research, amniotic f