模拟失重条件下肌梭改变与肌肉萎缩关系研究进展.pdfVIP

96 生理学报Acta Physiologica Sinica , February 25, 2013, 65(1): 96–100 综 述 模拟失重条件下肌梭的改变与肌肉萎缩关系的研究进展 1 , 赵雪红 ，樊小力2 * 1 441053 2 710061 湖北文理学院医学院机能学部，襄阳 ；西安交通大学医学院生理教研室，西安 / 摘 要：探明失重模拟失重状态下骨骼肌发生萎缩的机理，寻找出预防和治疗肌萎缩的有效措施，是航天医学亟待解决的重 要课题之一。研究资料表明，肌梭功能活动的改变可能与失重性肌萎缩的发生、发展有着密切的联系。本研究组多年来， 围绕着模拟失重条件下大鼠比目鱼肌肌梭的结构、代谢、功能等方面发生的改变展开了一系列研究。本文对我们已取得的 一些主要研究成果和相关研究作一综述，以期从模拟失重条件下肌梭改变方面来探讨失重性肌萎缩的发生机制，为制定更 有效的防治失重性肌萎缩的措施提供线索和依据。 关键词：肌梭；肌萎缩；模拟失重 中图分类号：R852.22 Relationship between simulated weightlessness-induced muscle spindle change and muscle atrophy 1 2,* ZHAO Xue-Hong , FAN Xiao-Li 1Medical Function Department, Medical College of Hubei University of Arts and Science, Xiangyang 441053, China; 2Department of Physiology, Medical College of Xi’an Jiaotong University, Xi’an 710061, China Abstract: One of the most important and urgent issues in the field of space medicine is to reveal the potential mechanism underlying the disused muscle atrophy during the weightlessness or microgravity environment. It will conduce to find out effective methods for the prevention and treatment of muscle atrophy during a long-term space flight. Increasing data show that muscle spindle discharges are significantly altered following the hindlimb unloading, suggesting a vital role in the progress of muscle atrophy. In the last de- cades, we have made a series of studies on changes in the morphological structure and function of muscle spindle following simulated weightlessness. This review will discuss our main results and related researches for understanding of muscle spindle activities during microgravity environment, which may provide a theoretic basis for effective preventi