上皮极性蛋白研究进展.pdfVIP

· 549 · 生命的化学, 2013, 33(5): 549-553 马远娜, 等. 上皮极性蛋白的研究进展 上皮极性蛋白的研究进展 1 2,3 1,2,3* 马远娜 ，王允山 ，吉爱国 1 2 3 ( 山东大学药学院，济南250012； 山东大学海洋学院，威海264209； 山东大学威海国际生物技术研发中心，威海264209) 摘要：极性蛋白(polarity protein)是指具有识别功能并且能够调节细胞极性的一类蛋白质，它们在 - (epithelial- 许多生理和病理过程如细胞增殖、细胞凋亡、细胞迁移、损伤修复、上皮 间充质转化 mesenchymal transition, EMT) 中具有重要作用，也在肿瘤的发生和发展过程中起到重要作用。本文拟 从上述几个方面对上皮相关极性蛋白的生物学功能做以综述，以期为疾病诊断和治疗提供新的思路。 关键词：上皮极性蛋白；生物学功能；疾病 Research progress of the epithelial polarity proteins 1 2,3 1,2,3* MA Yuanna , WANG Yunshan , JI Aiguo 1 2 ( School of Pharmaceutical Sciences of Shandong University, Jinan 250012, China; Marine college of Shangdong University, Weihai 264209, China; 3Shandong University-Weihai International Biotechnology Research and Development Center, Weihai 264209, China) Abstract: Polarity proteins function as multiprotein complexes that primarily regulate and identify the cell polarity. Studies have shown that polarity proteins are involved in many physiological and pathological processes including cellular proliferation and apoptosis, tissue repair, cell migration and epithelial- mesenchymal transition. Furthermore, epithelial polarity proteins have played an important role in the occurrence and the development of cancer. Therefore, we summarize the functions of epithelial polarity