玉米幼芽提取物对垂体后叶素致家兔心肌缺血的保护作用.pdfVIP

安徽农业科学,Journal of Anhui Agri .Sci .2007 ,35(7) :1945 - 1947 责任编辑 陈娟 责任校对 胡先祥 玉米幼芽提取物对垂体后叶素致家兔心肌缺血的保护作用 * 魏砚明, 欧阳五庆 , 张黎, 王俊, 申进宝 ( 西北农林科技大学动物科技学院, 陕西杨凌712100) 摘要 采 用耳缘静脉 注射垂体后叶素( pituitrin , Pit) 诱发家兔急性心肌缺血, 观察II 导联心电图心率、S-T 段位移及T 波波幅; 心肌酶( 谷 草转氨酶、乳酸脱氢酶、肌 酸激 酶) ; 心肌 组织 中谷 胱甘肽过 氧化 物酶( GSH- Px) 、超氧化物歧 化酶( SOD) 活性和 脂 质过 氧化物 丙二 醛 ( MDA) 含量的变化 。结果显示, 玉米幼芽提取物可减轻垂体后叶素诱发的家兔心电 图缺血性改变( 心率变缓、S-T 段抬 高、T 波高耸) , 抑 制血清中AST 、LDH、CK 活性的升 高, 并可增加缺血心肌组织中GSH- Px 和SOD 活性, 抑制MDA 含量升 高。结果表 明, 玉米幼芽提取物对 垂体后叶素致 家兔心肌缺血有一定的保护作用。 关键词 玉米幼芽提取物; 心肌缺血; 心电图; 心肌酶; 自由基 中图分类号 S852 .21 文献标识码 A 文章编号 0517 - 66 11(2007) 07 - 01945 - 03 Protective Effects of Extract of Maize Plumule on Myocardial Ischemia Induced by Pituitrin in Rabbits WEI Yan- ming et al ( College of Ani mal Science and Technology , Northwest Agriculture and Forestry University , Yangli ng , Shaanxi 712100) Abstract In lab experi ment the rabbit acute myocardial ische mia was induced by pituitrin ( Pit , 2 .0 U/ kg) inj ected intravenously . The index of heart rate , the locomotions of T wave and S- T section of lead II electrocardiogram ( ECG) , myocardial enzyme ( AST , LDH , CK) , and activities of gl utathione peroxidase ( GSH- Px) and superoxide dismutase ( SOD) and contents of malondiadehyde ( MDA) in the myocardium were examined . The results showed that extract of maize pl umule reduced the myocardial ischemic inj ury ( slowing of heart rate , run- up of T wave and S- T section) , restrai ned the rise of AST , LDH, CK activities in serum, increased activities of GSH- Px and SOD, and decreased MDA contents in the myocardium. These results demonstrat- ed the extract of maize plumule possessed the protective effects on acute myocardial ischemia induced by Pit . Key words Extract of maize plumule ; Myocardial ischemia ; Electrocardiogram; Myoca