无创正压通气治疗稳定期慢性阻塞性肺疾病的疗效.pdfVIP

·168· ．综述． 无创正压通气治疗稳定期慢性阻塞性肺疾病的疗效 罗祖金詹庆元 【擅要】无创正压通气(noninvasivepositivepressureventilation，NPPV)在慢性阻塞性肺疾病(chronic obstructive disease，COPD)急性加重期和稳定期患者中都有广泛应用。对于急性加重期患者， pulmonary NPPV可显著降低气管插管率、病死率、住重症监护病房(ICU)时间及住院时间等。对于稳定期患者， NPPV能显著改善呼吸困难症状及部分肺功能指标、提高Pa(h水平、缓解呼吸肌疲劳、增强活动耐力以及 改善睡眠和生活质量．但对于NPPV能否显著降低PaCOz水平，降低住院率、病死率、住ICU时间以及住 院时间等，尚存在较大争议。充分了解NPPV在稳定期COPD患者中的疗效，对于提高NPPV的临床应用 水平具有重要意义。 【关键词】稳定期慢性阻塞性肺疾病，无创正压通气；疗效 Treatmentoutcomeofnoninvasive ventilationinstablechronicobstructive disease positivepressure pulmonary LU0 Institute Zu-jin，ZHANQing-yuan．BeijingofRespiratoryMedicine，Be(iingChaoyangHospital to Medical a}{liatedCapital University，Beijing100020，C孔ina [Abstract]Noninvasiveventilation(NPPV)isin with positivepressure beingwidelyappliedpatiems andstablechronicobstructive disease(COPD)．TheuseofNPPVin with exacerbating pulmonary patients acute of showntoreducetheneed shortenthe exacerbationCOPDhasbeen forintubationand mortality，and ofICU and theuseofNPPVin withstableCOPDhasbeenshowna length stay hospitalstay．And patients muscle in function， significantimprovementdyspnoea，breathingpattern，arterialoxygentension，respiratory tO exercise and oflife．However，therewasnoconsistentevidenceconfirmthatNPPV tolerance，sleepquality candecreasearterialcarbon and shortenthe dioxidetension，reduceadmissions hospital mortality，and length ofICU and