茶儿茶素对小鼠的辐射防护作用.pdfVIP

1621 2006;26(11) 南方医科大学学报 (JSouthM edUniv) 茶儿茶素对小鼠的辐射防护作用 石卫民!赵新萍!芦婷广州军区广州总医院肿瘤科!广东广州 510010# 摘要 目的 探讨儿茶素对小鼠的辐射防护作用 方法 采用 直线加速器一次性全身照射小鼠 儿茶素加照射组 ! % 6M V X # % ’ ’ 以 200mg/kg d儿茶素灌服动物 10d后施行照射 比较两组小鼠体质量变化 外周血白细胞总数 平均存活时间及 30d % # # 生存率 结果 儿茶素加照射组小鼠体质量减轻低于照射组 平均生存时间明显长于照射组 30d存活率比对照组明显 而且儿茶素能加快单纯受照射小鼠外周血白细胞的恢复 结论 儿茶素对受照射小鼠有明显的辐射防护作用 升高# % % ! ( ( ( 关键词 儿茶素 辐射防护 体质量 存活率 中图分类号! 文献标识码! 文章编号! ! R852.7;R142!!!!!!!! A!!!!!!!! 1673-4254 2006 11-1621-02 !#$%’%()*($+) ),,)*( %, *()*-$.)/ 0$./( ’#$($%. $.12’3 $. 4$*) SHIW ei-m in,ZHAO Xin-ping,LU Ting Departm entofOncology,GuangzhouGeneralHospitalofGuangzhouComm and,Guangzhou 510010,China 56/(’*(7 861)*($+) To study theradioprotectiveeffectofcatechinesagainstradiation injury inm ice.!9)(-%#/ Catechines were adm inistered in m ice intragastrically atthe daily dose of200 mg/kg for 10 consecutive days before whole body irradiation with 6Gy X -rays.Thebody weightchanges,survivaltim e,30-day survivalrate,and countsofperipheralwhite blood cellswererecorded. !)/2:(/ Them icewith catechinepre-treatm entbeforeX -ray exposuresuffered lessbodyweight lossthanthosewithoutthetreatm entbeforeexposure. Catechinesm arkedly increasedthesurvivaltim eoftheirradiatedm ice, and raised the30-d survivalrateofthe irradiatedm iceto 53.33% ascomparedwith therateof13.33% in theradiatedm ice withoutcatechinep