氯替泼诺治疗中重度干眼抗炎作用的临床分析.pdfVIP

486 Medical Science Journal of Central South China,Sep2013,Vol.41,No.5 文章编号:2095-1116(2013)05-0486-04 ·临床医学· 氯替泼诺治疗中重度干眼抗炎作用的临床分析 曾摇 凤,卢亚梅,周元清,陈永铃 (暨南大学医学院附属清远医院眼科,广东 清远511500) 摘摇 要:摇 目的摇 观察0.5%氯替泼诺滴眼液治疗中重度干眼病的临床疗效。 摇 方法摇 按标准纳入中重度干 眼患者40例,回顾性分两组:联合用药组予0.5%氯替泼诺滴眼液和新泪然滴眼液联合用药;单用药组用新泪然滴 眼液。 在治疗前及治疗后2、4、6周观察眼表疾病指数(OSDI)、泪膜破裂时间(BUT)、泪液分泌实验(Schirmer I试 验)、眼表染色评分(OSS评分)、眼压;ELISA测泪液中炎症介质白介素鄄6(IL鄄6)的表达。 摇 结果摇 治疗2 周后,联 合用药组OSDI评分均值明显降低,较治疗前差异有显著性(P0.05);治疗2周联合用药组眼表炎症体征减轻;联 合用药组BUT均较治疗前延长;两组各时间点的Sehirmer I及眼压值无明显变化。 摇 结论摇 0.5%氯替泼诺滴眼液 通过下降IL鄄6表达,减轻中重度干眼眼表炎症,安全有效。 关键词:摇 干眼;摇 氯替泼诺;摇 炎症介质 中图分类号:R77摇 摇 摇 文献标识码:A Clinical Research of Anti鄄inflammatory Effects of Loteprednol Treat Moderate to Severe Dry Eye ZENG Feng,LU Yamei,ZHOU Yuanqing,et al (Department of Ophthalmology,QingyuanAffiliated Hospital of Jinan University,Qingyuan, Guangdong 511500,China) Abstract:摇 Objective摇 To observe the effect of0.5% loteprednol eye drops on the clinical efficacy of moderate鄄se鄄 vere dry eyeandinvestigatethepotential mechanismof loteprednol eyedropsinanti鄄inflammation.摇 Method摇 40 casesof moderate鄄severe dry eye patients according to the clinical standards were randomly divided into two groups:Experimental group (0.5% loteprednol eye drops together with Hypromellose 2910 eye drops);The control (Hypromellose 2910 eye drops).After treatment of loteprednol eye dropsfor2,4,6weeks,andocular Surface Disease Index(OSDI),tearfilmbreak鄄 up time(BUT),Schirmer test I(Schirmer I test),ocular surface staining(OSS) score and intraocular pressure were ob鄄 served,the IL鄄6 expression inthetearfluidwasdetectedby