奥沙利铂联合恩度介入治疗原发性肝癌疗效观察.pdfVIP

500 Medical Science Journal of Central South China,Sep2013,Vol.41,No.5 文章编号:2095-1116(2013)05-0500-05 ·临床医学· 奥沙利铂联合恩度介入治疗原发性肝癌疗效观察 廖明初,艾小红 (南华大学附属第一医院肿瘤内科,湖南衡阳421001) 摘摇 要:摇 目的摇 探讨奥沙利铂联合恩度在未切除的原发肝癌介入治疗中的疗效及不良反应。 摇 方法摇 回顾 性收集原发肝癌患者99例,其中48例灌注奥沙利铂联合恩度治疗,为联合治疗组。 51例仅灌注奥沙利铂治疗,为 奥沙利铂组。 摇 结果摇 联合治疗组客观缓解率为91%,显著高于奥沙利铂组(74%)(P =0.0024)。 经统计学处理 发现,奥沙利铂联合恩度灌注法与其客观缓解率有较高相关性,为其相关独立因素(HR =0.18;P =0.012)。 而总 的不良反应发生率联合治疗组为50%,奥沙利铂组为49%,两组比较无差异(P=0.575)。 摇 结论摇 奥沙利铂联合 恩度在原发肝癌介入治疗中具有较好疗效且不良反应轻。 关键词:摇 奥沙利铂;摇 恩度;摇 原发性肝癌;摇 疗效 中图分类号:R735郾7摇 摇 摇 文献标识码:A The Effect Observation of Oxaliplatin Combined with Rh鄄endostatin in Transarterial Chemoembolisation of Primary Hepatocellular Carcinoma LIAO Mingchu,AI Xiaohong (The FirstAffiliated Hospital,University of South China,Hengyang,Hunan421001,China) Abstract:摇 Objective摇 To evaluatethe initial safety and efficacy of combination therapy using oxaliplatin plus rh鄄en鄄 dostatinfor transarterial chemoembolisation(TACE)of unresectable hepatocellular carcinoma(HCC).摇 Methods摇 Patients whounderwent TACE using oxaliplatin plusrh鄄endostatin(n=48) and control patientswho underwent TACE using oxalipla鄄 tin鄄alone(n=51)were included in this study.摇 Results摇 The objective response rate in the oxaliplatin plus rh鄄endostatin group(91%)was significantly higher thanthat intheoxaliplatin group(74%,P=0.024).Useof oxaliplatin andrh鄄endosta鄄 tinwas an independent factor associated with higher objective response rate(hazard ratio=0.18;P =0.012).Overall inci鄄 dence adverse eventswasnotsignificantlydifferentbetweentheoxaliplatinplusrh鄄endostatingroup(50%)andtheoxaliplatin group(49%,P=0.575).摇 Conclusion摇 TACE using oxaliplatin plus rh鄄end