选择性剪接在Toll样受体4信号转导通路中的作用.pdfVIP

18 4 Vol. 18, No. 4 2006 8 Chinese Bulletin of Life Sciences Aug., 2006 1004-0374(2006)04-0391-06 Toll 4 (, 400010) Toll 4(Toll-like receptor4 TLR4)G- (lipopoly-saccharides LPS) MyD88 MyD88 -κB(NF-κB) TLR4 TLR4 T L R 4 Q538; Q501 A The role of alternative splicing in the Toll-like receptor 4 signal transduction LI Hong-Zhong, WAN Jing-Yuan*, ZHOU Qi-Xin (Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Unversity of Medical Sciences, Chongqing 400010, China) Abstract: Toll-like receptor4 (TLR4) is the primary recognition molecule for inflammatory responses initiated by bacterial lipopolysaccharides(LPS). After LPS is recognized by TLR4, the transcription factors such as nuclear factor-κB (NF-κB) can be expressed through MyD88-dependent pathway or MyD88-independent pathway subsequently, which can induce the cytokines production provoking systematical inflammatory reaction. Al- ternative splicing plays important roles in the eucaryotic gene expression, and a great deal of signaling mol- ecules in the TLR4 passageway can be alternative spliced naturally. Furthermore, a majority of the isomerides can negatively modulate TLR4 signal transduction. Key words: TLR4 lipopolysaccharides signal transduction alternative splicing Toll 4 (Toll-like receptor 4TLR4) adaptor molecule,TRIF)TRIF (lipopolysaccharidesLPS) (TRIF-related adaptor molecule, TRAM) MD-2 LPS TLR4 TLR4 TLR4 MyD88 IL-1 88 -1(IL-1 receptor associated kinase-1, IRAK-1) (myeloid differentiation factor88, MyD88)Toll/IL-1 -6 (TNF-receptor associ- (Toll/IL-