APPL1与新诊断2型糖尿病的相关性研究作者标注要清楚,包.docVIP

APPL1与新诊断2型糖尿病的相关性研究 上已发文章格式进行标注！ 王玉环张敏* 闫丽丽# 丁石梅 谢璇 西安交通大学医学院第二附属医院内分泌科 （* 西安交通大学医学院在读硕士 # 河北省秦皇岛市第一医院） [摘要] 目的 测定新诊断2型糖尿病患者血清磷酸酪氨酸衔接蛋白（APPL）1水平，分析血清APPL1水平与体质指数（BMI）、体脂分布（MHR）、收缩压（SBP）、舒张压（DBP）、空腹血糖(FPG)、糖化血红蛋白（HbA1c）、胰岛素抵抗指数（HOMA-IR）等的关系，初步探讨新诊断2型糖尿病患者血APPL1水平的变化。方法 应用酶联免疫吸附法（ELISA）对临床上新诊断的2型糖尿病患者63例（病例组）和健康对照者22例（对照组），进行空腹血清APPL1水平测定。稳态模型（HOMA-MODEL）计算胰岛素抵抗指数（HOMA-IR）。 结果 （1）病例组血清APPL1水平（85 .71 ± 27. 39）pg/ml显著高于对照组（64. 512± 16 . 28）pg/ml ，差异有统计学意义（P0.01）；（2）2型糖尿病（T2DM）组BMI、WHR、SBP、FINS、LgHOMA-IR均高于对照组(P0.01)，LDL高于对照组（P0.05）；而T2DM组高密度脂蛋白胆固醇（HDL-C）显著低于对照组（P0.01）；（3）APPL1与空腹血糖（FPG）、空腹血胰岛素（FINS）、胰岛素抵抗指数（LgHOMA-IR）呈显著正相关关系（r=0.215、0.297、0.334，P=0.014、0.006、0.002）；（4）以APPL1为应变量进行多元线性回归分析，结果胰岛素抵抗指数（β=0.329，P=0.002）进入方程。结论 新诊断2型糖尿病患者血清APPL1水平增高，APPL1可能与2型糖尿病的发生发展密切相关。 [关键词] 2型糖尿病；磷酸酪氨酸衔接蛋白；空腹胰岛素；胰岛素抵抗 Associational study between APPL1 and Newly Diagnosed Type 2 Diabetes Mellitus. WANG Yu-huan, ZHANG Min, YAN Li-li, DING Shi-mei, XIE Xuan. Department of Endocrinology,The Second Hospital, Xi＇an Jiaotong University, Xi＇an 710004,China Corresponding author:WANG Yu-huan,Email:wangyuhuan369@126.com. [Abstract] Objective In order to explore the changes of APPL1 levels in diabetes, we investigated the level of serum APPL1 in patients with newly diagnosed T2DM , analyzed the correlation between serum APPL1 and BMI,MHR,SBP,DBP,FPG,HbA1c,HOMA-IR. Method APPL1 levels were determined by ELISA in 22 normol controls (control group) and 63 newly diagnosed T2DM patients( T2DM group). HOMA-IR was calculated by HOMA-MODEL. Results (1) The levels of serum APPL1 in the T2DM group were significantly higher than that in control group [（85 .71 ± 27. 39）pg/ml vs （64. 52± 16 . 28）pg/ml , P0.01]; (2)BMI,WHR,SBP,FINS,LgHOMA-IR in T2DM group were higher than that in control group(P0.01),LDL was higher than the control group,but HDL-C in T2DM group was lower than that in control group(P0.01). (3) Fasting serum APPL1 levels were positively correlated with F