卡培他滨联合奥沙利铂治疗晚期结肠癌37例疗效观察.pdfVIP

论　　著 Lunzhu　　《中外医学研究》第 11 卷 第 33 期（总第 221 期）2013 年 11月 卡培他滨联合奥沙利铂治疗晚期结肠癌37例 疗效观察 　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　李怀① 【摘要】　目的： 方法： 　　 探讨卡培他滨联合奥沙利铂治疗晚期结肠癌的临床效果。 选择笔者所在医院晚期结肠癌患者共 37 例，均给予卡培他滨联 合奥沙利铂，观察本组患者近期临床效果及不良反应发生情况。结果：本组患者完全缓解率 5.4%，部分缓解率 35.1%，稳定率 35.1%，进展率 24.3%； 有效率 40.5%，临床获益率 75.7%。本组患者治疗过程中，严重不良反应主要为神经毒性和手足综合征，其发生率分别为 54.1% 和 29.7%。结论：卡培 他滨联合奥沙利铂治疗晚期结肠癌近期疗效显著，不良反应轻，患者可耐受，值得临床推广应用。 【关键词】　 　　 结肠癌；　晚期；　卡培他滨；　奥沙利铂 　　 中图分类号　R735.3 文献标识码　A 文章编号　1674-6805(2013)33-0010-02 　　Clinical Observation of Capecitabine Combined with Oxaliplatin in the Treatment of 37 Cases with Advanced Colorectal Cancer/LI Huai.//Chinese and Foreign Medical Research，2013，11(33)：10-11 　　【Abstract】　Objective：To explore the clinical effect of capecitabine combined with oxaliplatin in the treatment of advanced colorectal cancer.Method：Thirty- seven cases with advanced colon cancer were selected.All patients were given capecitabine combined with oxaliplatin.Clinical effect and adverse reaction incidence of all patients were observed.Result：The rate of complete remission in the group was 5.4%，the rate of partial remission was 35.1%，the rate of stabilization was 35.1%，the rate of progression was 24.3%.The effective rate was 40.5%.The clinical benefit rate was 75.7%.Hand-foot syndrome and neurotoxicity were the serious adverse reactions，the incidence rates were 54.1% and 29.7% respectively.Conclusion：Capecitabine combined with oxaliplatin in the treatment of advanced colorectal cancer has significantly clinical efficacy，and have lower adverse reaction incidence，have tolerance to adverse reactions by patients.It is worthy of clinical popularization and application. 　　【Key words】　Colon cancer；　Advanced；　Capecitabine；　Oxalipl