中西医结合防治小儿支气管哮喘合并反复呼吸道感染的临床观察.DOCVIP

临床医学论文-中西医结合防治小儿支气管哮喘合并反复呼吸道感染的临床观察 【摘要】? 　　目的 观察中西医结合防治小儿支气管哮喘合并反复呼吸道感染（RRI）的临床疗效。方法 将62例小儿支气管哮喘合并RRI患儿随机分为2组，对照组30例给予规律吸入糖皮质激素（ICS）及西药抗感染对症治疗，治疗组32例在对照组治疗基础上加服中药益肺健脾化瘀方，每日1剂，水煎温服。2组均1个月为1个疗程，连续治疗3个疗程，随访6个月，观察2组患儿临床疗效、RRI及哮喘临床症状，血清免疫球蛋白(Ig)、T细胞亚群的变化。结果 与对照组比较，治疗组治疗后呼吸道感染次数、发热天数、抗生素使用天数、咳嗽及气喘发作天数均减少，差异均有统计学意义(P0.01)。治疗组治疗后血清IgA、IgG及CD3、CD4 、CD4/CD8明显增高，CD8明显降低，与治疗前及对照组治疗后比较，差异均有统计学意义（P0.05，P0.01）。结论 小儿支气管哮喘合并RRI经ICS控制不理想儿童加用中药益肺健脾化瘀方能有效预防RRI，从而减少哮喘发作的次数，减轻哮喘严重程度。 【关键词】? 补脾益肺；祛瘀；呼吸道感染；哮喘 　　Observation of Combination of Traditional Chinese medicine and western medicine on children bronchial asthma complicated with recurrent respiratory infection???? 　　【Abstract】? Objective? To observe and study the curative effect of children bronchial asthma complicated with recurrent respiratory infection (RRI) treated by integrated traditional Chinese medicine and western medicine.Methods?62 patients were divided into 2 groups, which were treated with regular inhalation of corticosteroid (ICS) and anti-infective and symptomatic therapy, but nourishing the lung and strengthening the spleen and removing blood stasis decoction of traditional Chinese materia was given additionally to patients in the treatment group. Changes in clinical symptoms of RRI and asthma as well as the serum contents of immunoglobulin and T-cell subpopulation were observed.Results? Compared with the control group, the frequency of respiratory infection occurred, duration of fever, cough and asthma sustained and time of antibiotics used were all lower significantly in the treated group (P＜0.01).The serum contents of IgA, IgG and CD3、CD4,CD4/CD8 increased and CD8 decreased in the treatment group after treatment,as compared with those before treatment and in the control group, all showed significant difference (P＜0.05).Conclusion? For children suffered from intractable bronchial asthma complicated RRI, application of nourishing the lung ,strengthening the spleen and removing blood stasis decoction in addition w