间苯三酚在产程中应用的研究.DOCVIP

临床医学论文-间苯三酚在产程中应用的研究 ??????????????????????? 作者：范霞，迪丽努尔，张艳燕? 【摘要】? 目的 观察间苯三酚在产程进展中作用。方法 选择正常初产妇，宫口开大2～3 cm，伴宫颈水肿90例。随机分为间苯三酚组(46例)，待宫口开大2～3 cm后，给予间苯三酚8 mg静脉推注，阿托品组50例，待宫口开大2～3 cm后，给予阿托品0.5 mg宫颈注射。观察两组产妇用药后的产程变化及围产结局。结果 (1)用药至宫口开全的时间，间苯三酚组平均为(3.1±0.31)h，阿托品组平均为(4.4±0.4)h，两组比较，差异有显著统计学意义(P0.01);(2)用药后2 h的宫颈水肿消失率，间苯三酚组为95.6%，阿托品组为90.2%，两组比较，差异无统计学意义(P0.05)，较用药前平均宫口开大，间苯三酚组为(4.3±0.2)cm，阿托品组平均为(2.5±0.3)cm，两组比较，差异有显著统计学意义(P0.01);(3)间苯三酚组产妇及胎儿未发现明显不良反应;阿托品组用药后15～30 min，8例产妇诉口干，22例产妇心率每分钟增加10～15次，同时伴胎心率基线升高，约60 min后恢复;(4)阴道分娩率，间苯三酚组为95.6%，阿托品组为90.2%，两组比较，差异无统计学意义(P0.05);(5)产时羊水情况，新生儿窒息情况及新生儿体重在两组间比较，差异无统计学意义(P0.05);(6)两组产妇产后出血量比较，差异无统计学意义(P0.05)。结论 间苯三酚对促进产妇宫口扩张，加速产程进展有良好的作用，且对母儿无明显的不良影响。 【关键词】? 间苯三酚;子宫颈;分娩发作 　　[Abstract] Objective To observe the phloroglucinol role in the birth process.Methods Normal primipara with 2～3 cm miyaguchi and cervical edema 90 cases were selected，were randomly divided into two groups，phloroglucinol group 46 cases，were given phloroglucinol 8 mg in intravenous injection，Atropine group 50 cases were given Atropine 0.5 mg in cervical injections.Production process changes and perinatal outcome were observed after administration.Results Time from cervix with medication to full open in phloroglucinol group was(3.1±0.31)h，(4.4±0.4)h in Atropine group，the difference was significant.Cervical edema disappearance rate in 2 h after treatment was 95.6%，90.2% in phloroglucinol group and Atropine group，the difference was not significant.Miyaguchi was(4.3±0.2)cm，(2.5±0.3)cm in phloroglucinol group and Atropine group，the difference was significant.Maternal and fetal did not find significant side effects in phloroglucinol group，in 15～30 min after Atropine in Atropine group，8 cases had dry mouth，22 had rapid heart rate which increased 10～15 times per minute，and baseline fetal heart rate increased，then recoveried after 60 min.Vaginal delivery rate was 95.6%，90.2% in phloroglucinol group and Atropine group，the difference was not significant.Amniotic fluid situation，t