巴曲酶治疗急性脑梗死临床疗效的Meta 分析①.pdfVIP

- 204 - 中国康复理论与实践2013 年3 月第19 卷第3 期 Chin J Rehabil Theory Pract, Mar. 2013, Vol. 19, No.3 DOI : 10.3969/j.issn. 1006-9771.2013.03.002 ·专题· 巴曲酶治疗急性脑梗死临床疗效的Meta 分析① 1 1 1 1 1 2 程记伟 ，白宇 ，张晓菁 ，候郁青 ，张利军 ，陈学芬 [摘要] 目的 评价巴曲酶治疗急性脑梗死的临床疗效。方法 检索有关巴曲酶治疗急性脑梗死的随机对照研究文献。采用 Jadad 评分评价纳入文献质量。采用RevMan 4.2 软件进行Meta 分析。结果 共有38 项研究纳入分析，其中阴性对照29 篇，降纤酶 对照6 篇，尿激酶对照3 篇。巴曲酶在有效率、降低神经功能缺损评分、降低纤维蛋白原方面优于阴性对照组(P0.05) ，在神经功 能缺损评分方面与尿激酶无显著性差异(P0.05) ，在有效率方面与降纤酶无显著性差异(P0.05) 。结论 巴曲酶可改善急性脑梗死 患者神经功能缺损评分，降低纤维蛋白原水平。 [关键词] 急性脑梗死；巴曲酶；Meta 分析；神经功能；纤维蛋白原 Effects of Batroxobin on Acute Cerebral Infarction: A Meta-analysis CHENG Ji-wei, BAI Yu, ZHANG Xiao-jing, et al. Department of Neurology, Putuo Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China Abstract: Objective To assess the clinical effect of Batroxobin on acute cerebral infarction. Methods Randomized controlled trials (RCTs) about Batroxobin used for acute cerebral infarction were recalled. The quality of the document were assessed with Jadad scale, and the RevMan 4.3 software was used for Meta-analysis. Results 38 RCTs were recalled. 29 trials were negatively controlled, 6 controlled with Defibrase, and 3 controlled with Urokinase. Batroxobin is more effective than negative controls on neurological function score and fibrino- gen (P0.05). There was no statistics difference between Batroxobin and Urokinase on the neurological function score (P0.05), as well as incidence of improvement between Batroxobin and Defibrase (P0.05). Conclusion Batroxobin can effectively improve the neurological function and reduce the fibrinogen for acute cerebral infarction. Key words: acute cerebral infarction; Batroxobin; Meta-analysis; neurological function; fibrinogen