我院254 例药品不良反应报告分析[J].pdfVIP

·不良反应监测· 我院254例药品不良反应报告分析 ＊ 覃鲁财 ，黄彩伴（广西壮族自治区龙潭医院药剂科，广西柳州 545005） 中图分类号 R969.3 文献标志码 C 文章编号 1001-0408（2013）06-0538-03 DOI 10.6039/j.issn.1001-0408.2013.06.23 摘 要 目的：了解我院药品不良反应（ADR ）发生的特点和规律。方法：采取回顾性调查分析的方法，对我院2009－2011年收集 到的254例ADR 报告，按照患者性别、年龄、给药途径、药品种类、ADR 累及器官或系统及临床表现等方面进行统计、分析。结果： 254例ADR 报告中，60岁以上患者发生ADR 比例最高，构成比为31.89％；引发ADR 的给药途径以静脉滴注给药和口服给药为 主，构成比分别为57.48％和40.94％；最易引起ADR 的药物为抗微生物药，构成比为61.81％；以皮肤及其附件损害最多，构成比为 29.92％。结论：临床应重视和加强ADR 监测，规范临床合理用药，保证患者用药安全。 关键词 药品不良反应；报告；分析；合理用药 Analysis of 254 Cases of Adverse Drug Reaction Reports in Our Hospital QIN Lu-cai ，HUANG Cai-ban （Dept. of Pharmacy ，Longtan Hostpital of Guangxi Zhuang Autonomous Region ， Guangxi Liuzhou 545005，China ） ABSTRACT OBJECTIVE ：To understand the characteristics and regularity of adverse drug reactions （ADR ）in our hospital. METHODS ：By retrospective study ，254 cases of ADR reports collected in our hospital from 2009 to 2011 were analyzed statisti- cally in respect of patients ’gender ，age ，route of administration ，drug categories ，organs or systems involved in ADR and clinical manifestations ，etc. RESULTS ：Among 254 cases of ADR reports ，the incidence of ADR in the age group above 60 occupied the highest percentage ，which was 31.89％；intravenous administration and oral administration took the main percentage ，accounting for 57.48％and 40.94％，respectively ；ADR was easily induced by antimicrobial drugs with constituent ratio of 61.81％；skin and its appendents impairment cases took the biggest percentage ，accounting for 29.92％. CONCLUSION ：Clinicians should pay atten- tion to and strengthen the ADR monitoring ，standardize clinical rational drug use and ensure patients ’medication safety. KEY WORDS Adverse drug reaction ；Report ；Analysis ；Rational drug use 按照世界卫生组织（WHO ）国际药物检测合作中心的规 2 结果 定，ADR 系指正常剂量的药物用于预防、诊断、治疗疾病或调