香菇多糖辅助治疗原发性肝癌的系统评价.docVIP

摘　　要　 香菇多糖辅助治疗原发性肝癌的系统评价  研究生：李源 摘  导师：温浩 教授 要  目的：系统评价香菇多糖辅助治疗原发性肝癌的临床疗效。方法：计算机检索 Cochrane 图书馆临床对照试验库；PubMed；MEDLINE；EMBASE；OVID；中国生 物医学文献数据库；中文科技期刊全文数据库；中国期刊全文数据库。按 Cochrane 系统评价方法评价纳入研究质量，并进行描述性分析。结果：共纳入 2 个随机对照 试验（RCT），包括 274 例患者。所有研究均报道采用了随机方法，均未详细报道随 机方案的隐藏情况及是否采用盲法。结果显示香菇多糖+肝动脉化疗栓塞术（ TACE） 组与单纯应用肝动脉化疗栓塞术（ TACE）组相比，香菇多糖+TACE 组可提高肿瘤 体积减小率；提高 NK 细胞活性；提高 CD4 含量，CD8 含量降低； IL2 含量提高； sIL-2R 表达水平降低。但香菇多糖+TACE 治疗组与 TACE 组的 AFP 降低率差异无统 计学意义。结论：目前研究显示香菇多糖辅助治疗原发性肝癌可提高机体免疫力， 在抗肿瘤方面有一定优势。本系统评价纳入的研究少，每个研究纳入测量指标不同， 影响了本系统评价的论证强度及全面性。因此我们期待更多的高质量随机对照试验 出现，能进一步完善评价。 关键词：香菇多糖；原发性肝癌；系统评价 —1— 新疆医科大学医学硕士学位论文　 The application of Lentinan for the adjuvant treatment of Hepatocellular carcinoma: a systematic review  Postgraduate: Li Yuan  Supervisor: Prof. Wen Hao  Abstract Objective:To systematic review the curative effect of lentinan for the adjuvant treatment of Hepatocellular carcinoma. Methods: We searched the Cochrane Library Controlled Trials database; PubMed; MEDLINE; EMBASE; OVID; Chinese Biomedical Literature Database; English CJFD Technology; CJFD. According to Cochrane systematic reviews to evaluate the quality of the study and make a descriptive analysis. Results: A total into two randomized controlled trials (RCT), including 274 cases of patients. All studies have reported the use of a random method, no detailed reports on the hidden random program and whether to adopt the blind. The results showed that lentinan + hepatic arterial chemoembolization (TACE) group compared to the simple application of hepatic arterial chemoembolization (TACE) group, Lentinan + TACE group could enhance the rate of tumor volume decrease; enhance NK cell activity; improve CD4 content, decrease CD8 content ; improve IL2 content; sIL-2R expression decreased. But Lentinan + TACE group and TACE group to reduce the rate of AFP was no significant difference. Conclusion: The present study shows that the application of Lentinan for the adjuvant treatment of Hepatocellular carcinoma can improve