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目 录
中文摘要 ···················································1
英文摘要 ···················································3
引 言 ····················································6
正 文 ····················································7
第一部分 理论研究 ···········································7
第一节 高血压病的中医理论认识 ·······························7
1 病因病机 ···················································7
2 高血压病中医辨证分型·······································9
3 治疗高血压病的中药现代药理学研究 ··························11
4 高血压病肝阳上亢证的研究概述······························12
第二节 天麻钩藤饮治疗高血压病的研究概述 ···················17
1 天麻钩藤饮治疗高血压病的临床疗效 ··························17
2 天麻钩藤饮治疗高血压病的机理研究进展 ······················18
第三节 高血压病的现代医学认识······························21
1.内皮素及其受体与高血压的关系······························22
2．一氧化氮和一氧化氮合酶与血压的关系 ·······················23
3 高血压病与血管内皮功能的关系······························25
第四节 正交设计在中医药研究中的应用 ·······················29
1．正交设计应用于中药复方研究中的特点 ·······················29
2．正交设计应用于中药复方研究的优势和意义 ···················29
第二部分 实验研究 ··········································31
第一节 优化处方筛选方案·····································31
第二节 实验材料 ············································32
1 实验动物··················································32
2 实验药物及试剂仪器········································32
1
第三节 实验方法 ············································33
1．肝阳上亢证高血压模型的复制方法 ··························33
2 动物分组与给药 ···········································34
3 观测项目与方法 ···········································35
第四节 实验结果 ············································38
1 各组动物血压变化比较 ······································37
2 各组动物行为学观察变化比较 ································38
3各组动物给药后血清NO、NOS、ET 含量比较 ····················42
第五节 讨论 ················································43
1.关于动物模型的制备······································43
2.关于高血压的发病机制····································44
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