部分液体通气治疗ARDS犬的实验研究.DOCVIP

临床医学论文-部分液体通气治疗ARDS犬的实验研究 ???????????????????????????????????????????? 作者：马龙先 朱小萍 赵为禄 【关键词】? 呼吸功能 　　【摘要】 目的? 观察部分液体通气（partial liquid ventilation，PLV）对急性呼吸窘迫综合征（ARDS）犬的肺内气体交换、肺顺应性及肺动静态阻力的影响。 方法? 健康家犬12只，用油酸制备成ARDS模型后，随机分为两组，各组治疗方法不同。生理盐水组（对照组）:肺内注入生理盐水（NS），同时行常规机械通气（CMV），另加呼气末正压通气（PEEP）;氟碳组（治疗组）:肺内注入氟碳（PFC），同时行CMV+PEEP。分别观察通气治疗后各组30、60、90、150min时血气分析、呼吸力学的变化。 结果? 实施PLV后，ARDS犬动脉血PaO 2进行性上升，从（84.23±22.60）mmHg上升到（174.53±76.59）mmHg，到150min最高达到（267.43±75.83）mmHg，各时间段与治疗前比较差异均有显著性（P0.05）。治疗组肺顺应性在各时间段与治疗前比较差异无显著性，对照组肺顺应性在各时间段呈下降趋势，到150min时与治疗前比较差异有显著性（P0.05）。 结论 PLV治疗急性呼吸窘迫综合征能有效提高动脉氧合，改善肺顺应性。???? 　　关键词? 部分液体通气 氟碳 急性呼吸窘迫综合征 呼吸功能?????? 　　Exprimental study on partial liquid ventilation in treatment of ARDS dogs????? 　　Ma Longxian，Zhu Xiaoping，Zhao Weilu???? 　　Anesthetic Department，The First Affiliated Hospital of Jiangxi Medical College，Nanchang330006.??? 　　【Abstract】 Objective To observe the effectiveness of partial liquid ventilation（PLV）on gas exchange，pul-monary（Cst）and airway resistance in dogs with ARDS.Methods Twelve dogs were randomly allocated to two groups and treated with various methods after OA ARDS model established.The study groups as follows:normal saline（NS）groups（the control group）with CMV，PEEP and NS;PFC group（the treatment group），with CMV，PEEP and PFC.The parameters such as blood gas analysis，airway resistance and pulmonary compliance were observed at30，60，90，150minutes after ventilation.Results After PLV，PaO 2 increased progressively，which was significantly higher than pre-treatment value at all time points（P0.05）.It increased from84.23±22.60mmHg to174.53±76.59mmHg，and to the highest267.43±75.83mmHg at150minutes Cst in treatment group exhibited to difference to the pre-treatment value at all time points，while Cst in control group decreased at all time points and at150minutes significant difference appeared（P0.05）.Conclusion The oxygenation and Cst improve significantly during PLV in ARDS.??? 　　Key words partial liquid ventilation perfluorocarb