喹硫平单药治疗双相障碍躁狂发作疗效研究.pdfVIP

中华临床医师杂志( 电子版)2013 年12 月第7 卷第23 期 Chin J Clinicians(Electronic Edition),December 1,2013,Vol.7,No.23 ·10717 · ·临床论著· 喹硫平单药治疗双相障碍躁狂发作疗效研究 刘珺 管娟 王铭 【摘要】 目的 评价喹硫平单药治疗双相障碍躁狂发作的疗效与安全性。方法 102 例双相躁狂患者 随机分为喹硫平组（51 例）和碳酸锂组（51 例），均治疗8 周。于治疗前及用药后第1、2、4 、6、8 周分 别采用阳性症状与阴性症状量表（PANSS ）、杨氏躁狂量表（YMRS ）、临床疗效总评量表双相障碍版-严 重程度分量表 （CGI-BP-S ）评定疗效，用副反应量表 （TESS ）评定不良反应，并定期进行体格检查和实验 室检查。结果 治疗后两组各量表分值均明显下降，两组症状均明显缓解，具有相似的药物应答，其中喹 硫平组杨氏量表评分从 31.49 ±6.22 降低至5.06 ±5.91 （P ＜0.01 ），碳酸锂组杨氏量表评分从32.83 ±5.57 降低至6.67 ±7.46 （P ＜0.01 ）；喹硫平组总有效率为92.2%，碳酸锂组为91.5%，两者差异无统计学意 义 （P ＞0.05 ），但喹硫平组痊愈率略高（64.77% vs. 碳酸锂组55.3% ），且不良反应 （如口干、嗜睡等） 较少，代谢指标变化小。结论 喹硫平单药治疗双相躁狂有确切疗效，不良反应少，药物耐受性好。 【关键词】 喹硫平； 单药治疗； 双相障碍躁狂 Study on the efficacy of quetiapine monotherapy in the treatment of bipolar type mania LIU Jun, GUAN Juan, WANG Ming. Wuhan Mental Health Center of Tongji Medical College of Huazhong University of Science Technology, Wuhan 430022, China Corresponding author: WANG Ming, Email: whwangming88@ 【Abstract 】 Objective To evaluate the efficacy and safety of quetiapine monotherapy in the treatment of bipolar type mania. Methods 102 patients were randomly received with quetiapine (n ＝51) or lithium (n ＝51) for 8 week. Patients were assessed with Young Mania Rating Scale (YMRS), Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression Scale-Bipolar disorder version- severity of illness (CGI-BP-S) at baseline and the end of 1st, 2nd, 4th, 6th, 8th to evaluate the efficacy. Treatment Emergent Symptom Scale (TESS) was performed to evaluate the adverse drug reactions, while physical examination and laboratory examination were used to evaluate the safety. Results Quetiapine was associated with significant, sustained improvement in manic symptoms compared with lithium. After 8 weeks, the mean YMRS