毛囊干细胞增殖与分化相关信号通路研究进展.pdfVIP

2010 2 24 2 中国修复重建外科杂志 年 月第 卷第 期 161 · · 毛囊干细胞增殖与分化相关信号通路研究进展 # 许永安 付小兵 【摘  要】 目的 对毛囊干细胞增殖与分化相关信号通路的研究现状与应用前景进行综述。  方法 查阅近年 国内外关于毛囊干细胞增殖与分化相关信号通路的研究文献，并进行回顾及综合分析。  结果 调节毛囊干细胞增殖与 分化的多条信号通路，包括BMP /TGF-β 、Wnt 、Notch 、外胚层发育不全基因等，在皮肤组织的发育、更新及修复过程中发 挥着重要调控作用。  结论 毛囊干细胞可作为皮肤创面修复的一种重要细胞学治疗方法。 【关键词】 毛囊干细胞 信号转导 细胞增殖 细胞分化    细胞治疗 中图分类号： R322  Q73 文献标志码：A DEVELOPMENT OF HAIR FOLLICLE STEM CELLS RELATED SIGNAL TRANSDUCTION IN PROLIFERATION AND DIFFERENTIATION/XU Yongan, FU Xiaobing. Key Laboratory of Wound Repair, First Affiliated Hospital, Chinese PLA General Hospital, Beijing, 100048, P.R.China. Corresponding author: FU Xiaobing, E-mail: fuxiaobing@ 【Abstract 】  Objective To introduce the basic research and clinical potential of the hair follicle stem cells related signal transduction in proliferation and differentiation. Methods The recent original articles about the hair follicle stem cells were extensively reviewed. Results Many different signal pathways had been involved in the skin development and self-newals.The hair follicle stem cells could play an important role in the skin self-renewal and regeneration which were modulated by several different signal pathways, which included bone morphogenetic protein/transforming growth factor β, Wnt, Notch and ectodysplasin A genes.  Conclusion The hair follicle stem cells may be a future approach to repair cutaneous wounds as a cell therapy ． 【Key words 】 Hair follicle stem cells Signal transduction Cell proliferation Cell differentiation Cell therapy Foun