普罗布考对急性脑梗死患者临床及血管内皮功能的影响.pdfVIP

Chinese Journal of New Drugs 2010, 19( 14) (武警河南总队医院, 郑州 450052) [] : 观察普罗布考对急性脑梗死患者临床及血管内皮 能的影响: 100例急性脑梗死 患者按入院顺序随机分为普罗布考组 54例和对照组 46例对照组用常规治疗方法治疗, 包括溶栓抗血小 板聚集( 阿司匹林 100mgd- 1 )治疗处理并发症及基础疾病等普罗布考组在常规治疗的基础上加服普罗 布考 0. 5 g, b id2组均连续治疗 6 个月于治疗前和治疗 1, 6 个月后进行神经 能缺损评分的评估, 治疗 前和治疗 6 个月后检测血脂和血管内皮 能指标的变化情况: 治疗 1, 6 个月后, 普罗布考组神经 能 缺损评分比治疗前均显著降低(P 0. 01), 比对照组均显著降低(P 0. 01); 用药 6 个月后普罗布考组血 脂血ET1及 oxLDL比对照组显著降低(P 0. 01或P 0. 05); 普罗布考组NO及 FMD比治疗前显著升高 (P 0. 05)对照组血NO, ET1, oxLDL及 FMD 治疗前后差异无统计学意义(P 0. 05)普罗布考组未发现 严重的不良反应: 普罗布考能显著地改善神经 能, 调整血脂代谢, 改善血管内皮 能, 且安全性好 [] 急性脑梗死; 普罗布考; 血管内皮 能 [] R 43. 3 [] A [] 1003- 3 34( 2010) 14- 123 - 04 Effect of probucol on the functional outcom e and vascular endothelial function in patients w ith acute cerebral infarction ZHANG Lufeng (H enan Arm ed Police Corp sH osp ital, Zhengzhou 450052, Ch ina) [Abstract] Objective: To observe the effect of probucol on the functional outcom e and vascular endothelial function in patientsw ith acute cerebral infarction. M ethods: A total of 100 patients w ith acute cerebral infarction w ere random ly d ivided into 2 groups. The patients in control group ( n = 46) were treatedw ith conventional therapy - 1 for 6months, including thrombolysis, antip latelet aggregation ( aspirin 100mgd ), decreasing intracranialpres sure, and treating comp lications and basic d iseases. The patients in probucol group ( n = 54) w ere treated for 6 monthsw ith probucol 0. 5 g, wt ice a day, in addition to conventional therapy. Neurological deficit score w as as sessed at 1 and 6 months. The serum lip ids and ind icators of vascular endothelial function were detect