凉血解毒汤对血热型银屑病患者血清TNF-αIL-6的影响_王丽华.pdfVIP

第 27卷 第 12期 Vol. 27No. 12 2009年 12月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE Dec. 2 0 0 9 TNF- A IL- 6 1 1 2 1 2 王丽华 ,张 蕾 ,刘志勇 ,李 萍 ,王莒生 ( 1., 100010; 2., 100010) :目的:探讨凉血解毒汤对血热型银屑 患者血清白细胞介素 IL- 6肿瘤坏死因子 TNF水平的影响, 以评价本药的临床疗效和药理机制方法: 随机选取 50例血热型银屑 患者为治疗组, 并设正常对照组,观察治 疗组治疗前后临床症状及其血中 IL- 6TNF水平的变化结果:血热型银屑 患者经凉血解毒汤治疗后, 患者 血清 IL- 6TNF显著含量降低(P 0. 05, 结论:凉血解毒汤通过清热解毒, 凉血活血等药理作用, 明显降低 IL- 6, TNF的血清含量,使患者免疫调节趋向正常 :血热型银屑 ;清热解毒, 凉血活血;TNF; IL- 6 : R285. 5 :A : 1673- 7717(2009) 12- 2583- 03 Effect ofLian TheGxue JieduDecoction in Serum TNF- A and IL- 6 Levels ofXuereTypes Syndrome ofPsoriasis 1 1 2 1 2 ANG L-ihua, ZHANG Lei, LIU Zh-iyong, LIPing, ANG Ju-sheng ( 1. Beijing Institute ofTraditionalChineseMedicine, Beijing 100010, China; 2. BeijingHospital ofTraditionalChineseMedicineAffiliated toCapitalMedicalUniversity, Beiing 100010, China) Abstrac:t O bj ectiv e: To assesdrug pharmacologicalmechanisms, the effectsofLiangxuejiedu in serum cytokines( in- terleukin, IL- 6 and tumor necrosis factor, TNF- A) levels in patients of psoriasiswere investigated.M ethods: Random ly selected 50 xuere types syndromeofpsoriasiswere treatedw ithLiangxuejiedu decoction for twomonthsin treating group, and 31healthy caseswere asa normal control group, and serum IL- 6 andTNF- A level changewere observedbefore and after treament.R esults: Theserum reducing IL- 6, levelswereobserved in treatedbyLiangxue jidu patientsof psoria- sis(P [ 0. 01), TNF- A level change tend to reduce. Conclusion: The study suggested thatLiangxue jiedu decoctionQin- grejiedu, Liangxuehuoxue pharmacological