海参虫草复剂降血糖作用研究.docVIP

海参虫草复剂降血糖作用研究 作者简介：李辉(1985—)，男，硕士研究生，研究方向为海洋生物活性物质。 通信作者：薛长湖，E-mail：xuech@ouc.edu.cn。 基金项目：国家自然科学基金项目30871944)；国家高技术研究发展计划项目(2007AA091805) 论文字数：5700 表格数目： 4 海参虫草复剂降血糖作用研究 李辉，王静凤，傅佳，李晓林，李冰，王玉明，薛长湖* （中国海洋大学食品科学与工程学院，山东，青岛 266003） 摘 要： 目的：探讨海参虫草复剂对糖尿病大鼠糖代谢的调节作用。方法：采用腹腔注射链脲佐菌素的方法建立糖尿病大鼠模型。利用海参虫草复剂(分别为300、1200mg/kg·bw35d，观察其对大鼠空腹血糖、葡萄糖耐量、血清胰岛素、糖化血红蛋白、糖化血清蛋白以及肌、肝糖元等的影响。结果：海参虫草复剂能显著降低糖尿病大鼠空腹血糖含量(P0.05)，提高葡萄糖耐量水平(P0.05，P0.01)(P0.05，P0.01)P0.05)、胰岛素分泌指数(P0.05)和β细胞功能指数(P0.05)；增加肌、肝糖元含量(P0.01)。结论：海参虫草复剂能改善糖尿病大鼠的糖代谢水平，具有较好的降血糖效果。 关键词：海参虫草复剂；胰岛素；糖化血红蛋白；糖化血清蛋白 THE ANTIHYPERGLYCEMIC EFFECT OF MIXTURE OF APOSTICHOPUS JAPONICUS AND CORDYCEPS MILITARIS IN DIABETIC RATS LI Hui, WANG Jing-feng, FU Jia, LI Xiao-lin, Li Bing, WANG Yu-ming, XUE Chang-hu* (College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China) Abstract: Objective: To investigate the effect of the mixture of Apostichopus japonicus and Cordyceps militaris on the glucose metabolism in diabetic rats that induced by STZ. Method: The diabetic rat model was established by intraperitoneal injection of STZ. The model rats were administrated the mixture of A. japonicus and C. militaris by oral for 35 days, and to observe the effect on fasting plasma glucose, glucose tolerance, serum insulin, glycosylated hemoglobin, glycosylated serum protein and muscle glycogen, as well as the liver glycogen in diabetic rats. Results: The mixture of A. japonicus and C. militaris can reduce the fasting blood glucose level (P0.05) and improve the glucose tolerance (P0.05, P0.01) obviously; significantly decrease the contents of glycosylated hemoglobin and glycosylated serum protein (P0.05, P0.01); and the mixture can also improve the level of serum insulin (P0.05), insulin secretion index (P0.05) and β-cell function index (P0.05); and increase the contents of muscle glycogen and liver glycogen (P0.01). Conclusion: The mixture of A. japonicus and C. militaris improved the glucose metabolism and have an as