帕罗西汀与舍曲林治疗早泄效果评价.docVIP

帕罗西汀与舍曲林治疗早泄效果评价 张卫星，秦俊昌，王 瑞，王 磊，张 杰 （450052 郑州，郑州大学第一附属医院泌尿外科，河南省高等学校临床医学重点学科开放实验室） [摘要目的评价长期服用帕罗西汀、舍曲类药物早泄的有效性和安全性。方法将郑州大学第一附属医院就诊符合“早泄诊断工具”早泄标准190例随机应用性行为暂停-阴茎挤捏(标准对照组)服帕罗西汀片（赛乐特）20、0 mg/d，服舍曲林片（左洛复）50、100mg/d 种不同治疗方法12周于治疗前6、12周监测：阴道内射精潜伏期时间intravaginal ejaculatory latency time，IELT）（问题3：第一次出现请给出其中英文全称），性生活满意度及不良反应。结果 14完成，治疗6周各IELT均高于治疗前0.05)，较更（t=3.92, p0.01）于治疗12周后SSRIs各组IELT均于(all p0.05)。不良事件无显著差异(χ2=, p0.05)。结论 帕罗西汀、舍曲林两类SSRIs药物早泄患者有效治疗早泄，耐受性以帕罗西汀疗效更为显著。关键词帕罗西汀；舍曲林；SSRIs；早泄；疗效Efficiency of SSRIs in treatment of premature ejaculation: An randomized study with paroxetine and sertraline Zhang WeiXing; Qin JunChang; Wang Rui; Wang Lei; Zhang Jie （Department of Urology, the First Affiliated Hospital of Zhengzhou University，The Key-Disciplines Laboratory Clinical-Medicine Henan Zhengzhou Henan 450052,China） Corresponding author:Wang Rui,E-mail: huzi918@ [Abstract] Objectives: This investigation was to evaluate the long term efficacy and safety of two kinds of SSRIs, Paroxetine and Sertraline in men of with premature ejaculation. Methods: This randomized trial enrolled 190 men who met the Premature Ejaculation Diagnosis Tool. They were randomized to use the pause-squeeze technique and to receive paroxetine 20mg, paroxeting 30mg, sertraline 50mg, sertraline 100mg daily. Before treatment, after 6 weeks and 12 weeks, self report IELT, satisfaction with intercourse, and adverse events ware investigated. Results: 148 participates completed this study. After 6 weeks’ treatment, IELT increased significantly from baselines(all p0.05), Paroxetine 30mg intake was much superior to pause-squeeze technique in improving IELT(t=3.92, p0.01); at 12 weeks, IELT was mach longer in patients with SSRIs than that with pause-squeeze technique. Rate of satisfaction with intercourse improved significantly with paroxetine 30mg at 12 weeks, which exceed 60%. The common adverse events for long time SSRIs treatment were drowsiness, headache, anypnia, diarrhea, however, and there were n