血清、唾液6-磷酸葡萄糖异构酶抗原检测在类风湿关节炎诊断及鉴别诊断中的意义.pdfVIP

ModIfiagn_rr㈨l 脱代诊 ，‘i 2010 I2I(1) 血清、唾液6一磷酸葡萄糖异构酶抗原检测在类风湿关节炎诊断及鉴 别诊断中的意义 林 星，吴茂春 ，陈 晗，俞建钰，陈 勇，魏忠光，郑明英({f建l科人 ： 教、：院．ff 打。 3503(X1) ClinicalSignificanceofDetectionofGlucose-6一PhosphateIsomeraseAntigen inSerum andSalivainDiagnosisandDifferentialDiagnosisofRheumatoid Arthritis LIN Xing，WU Mao-chun，CHEN Han，YU Jian-yu，CHEN Yong，WEIZhong-guang，ZHENG Ming- ying(FmlingTeachingHospitalo／’FufianMedicalUniversity，Fuqing350300， ) Abstract：Objective roassesstheclinicalsignificanceofglucose-6一phosphaleisomerase(GPI)antigenintli- agnosisantidiflbrentialdiagnosisofrheunmtoidarth,。iris(RA)．I,ytletectingG antigenantianti·cytlieeitrul— Iinate(1peptid(CCP)antil,,,,liesinsetu‘lnall(Isalivaol’I,atientswithRAan(Iuntilfrerenliate,Iarlh~’ills(UA)． Method The lewdsofserum (：1)1andanti—CCP autil,o,liesweretesterIin76patientswith RA ．10palienls withUA．16,ion-RAeonlrt,lswith,,tilerrheumatismand33normalsuhjectsI,ysandwichEl1SAmetho,is．rh,- levelsoI’salira(PIinfi,rly—1wopatientsantiallthem)rmalsubjectswerealsuteslet]．Results rhelevelsof’se- runiGP!antigeninRApatientswerehighei’thanthoseinbothnol’malsubjectsandpatientswithl，lhIr‘heu— matiediseases，whilethelattertwogroupshadno,lifferenees．When Ihecut—off valuewassetat0．391xg／ml withROCcurve，theyoudeindexwastilehighesl(0．528)，whilethesensitivityot。GP1was0．67I．theSl,eeifie— ilywas0．857 JrRA．Amongthe10UA patients．6patientswhowereIinallydiagn,,se,IasIIA werep,,sitiveof (Pfantigen．thtother4patientswe!。e,luringfidlow—Ul’．Conclusions Beeattseofhighsensitivityandspecille— iIyinI{A,liagnosis，lestIII-seruI1lGPIlevelscanI,eusedasanew ll,a,’ke,’orRAbesidesRFaudanti一【1I：I’all— til,odies．Itiscloselyeorrelativewithanti—CCPal,til,o,lies．rrhei,‘(．ombiuatiolimayin,l·easelint-,liagn,,slit·railol’ RA．ParticularlyinthedifferentiaIdiagnt,sisol’UA，itlinsinlIllrtanlsigniti’t~·!uee． Keywords：Ai’Ihritis；Rheumatoi,I；(；lue,)se-6一I,h,,s1)haleisomela‘se 摘要：目的 愉测 风 足 炎(RA)、术分化父1炎(I_A)心 1I彳l0Lf 澉 6一膦酸简柏概If件f