胶囊内镜下非甾体类抗炎药相关性小肠损伤特点分析.pdfVIP

·诊 断 剖 析 Western Journal of Traditional Chinese Medicine,2014 Vol.27 No.7 胶囊内镜下非甾体类抗炎药 相关性小肠损伤特点分析 魏丽娜，刘子燕，郝晋雍，黄晓俊△ 兰州大学第二医院消化科，甘肃 兰州 730030 ［摘 要］目的：分析非甾体抗炎药（NSAIDs）引起小肠损伤的胶囊内镜下特点。 方法：将小肠损伤患者 74 例根据 1 周前是否服用 NSAIDs 分为观察组与对照组，比较 2 组胶囊内镜下的病变部位和性质差异 。 结果：观 察组无症状为 71.4%，高于对照组 25.6%，差异具有统计学意义 (P ＜0.05)，对照组消化道出血、腹痛、腹泻均高 于观察组，差异具有统计学意义 (P ＜0.05)；观察组胶囊内镜下检查出溃疡率为 22.9%，高于对照组的 15.4%， 且具有统计学意义 (P ＜0.05)，对照组胶囊内镜下出血率、孤立溃疡率较观察组高，具有统计学意义 (P ＜0.05)， 肠黏膜糜烂 2 组比较未见明显差异 (P ＞0.05)。 结论：胶囊内镜下非甾体抗炎药的损伤主要为黏膜糜烂，其溃 疡表现为直径 ＜1 cm溃疡，多发，为表浅性溃疡，较未服用药者溃疡表现有较大差别，故胶囊内镜的使用有利 于鉴别及相关治疗，且检查前服用胃肠汤剂可有效减少胶囊滞留的发生，并有益于病变的检出。 ［关键词］小肠损伤；溃疡；非甾体抗炎药；胶囊内镜 ［中图分类号］R574.15 ［文献标识码］B ［文章编号］1004-6852(2014)07-0128-03 The Analysis on the Features of NSAIDs-related Small Intestine Injury under Capsule Endoscope WEI Lina, LIU Ziyan, HAO Jinyong, HUANG Xiaojun △ Gastroenterology Department of Lanzhou University the Second Hospital, Lanzhou 730030, China Objective: To explore the features of non-steroid anti-inflammatory drugs (NSAIDs) induced small intestine injury under capsule endoscope. Methods: Seventy-four patients were allocated to the observation group and the control group in accordance with whether they take NSAIDs one week ago, the lesions and the property of both groups were compared under capsule endoscope. Results: Asymptomatic ratio of the observation group was 71.4%, higher than 25.6% of the control group, the difference showed statistical meaning (P ＜0.05); the control group was higher than the observation group in the