甲巯咪唑致关节炎综合征一例并文献复习.pdfVIP

·88 · 中华临床医师杂志( 电子版)2014 年1 月第8 卷第1 期 Chin J Clinicians(Electronic Edition),January 1,2014,Vol.8,No.1 ·临床论著· 甲巯咪唑致关节炎综合征一例并文献复习 张方华 阎胜利 姚民秀 徐倩 王会玲 商永芳 李盈 【摘要】 目的 报道1 例服用甲巯咪唑（商品名赛治）出现抗甲状腺综合征的患者，并进行文 献复习。方法 对1 例30 岁女性服用赛治出现抗甲状腺综合征患者的临床资料进行回顾性分析，并 复习相关文献。结果 本例患者因甲状腺功能亢进症口服赛治（10 mg ，tid ）治疗，25 d 后出现游走 性多关节疼痛、活动受限。停用赛治，口服洛索洛芬钠（商品名乐松）治疗，关节疼痛好转。换用 丙硫氧嘧啶治疗，无不良反应。结论 口服赛治可发生抗甲状腺关节炎综合征，需立即停药。 【关键词】 甲巯咪唑； 抗甲状腺药； 关节炎综合征 Arthritis syndrome caused by thyrozol one case-report and literature review Zhang Fanghua, Yan Shengli, Yao Minxiu, Xu Qian, Wang Huiling, Shang Yongfang, Li Ying. Department of Endocrinology, The Second Affiliated Hospital of Qingdao University Medical College (Qingdao Central Hospital), Qingdao 266042, China Corresponding author:Yao Minxiu, Email:yaominxiu@ 【Abstract 】 Objective To report one case of taking thyrozol appears arthritis syndrome patients and a literature review. Methods A 30-year-old female patient with hyperthyroidism appeared arthritis syndrome after starting therapy with the antithyroid drug thyrozol.The patient clinical data were retrospectively analyzed, and review of the literature. Results The patient with hyperthyroidism due to oral thyrozol (10 mg tid) therapy 25 days, her joint happened the migratory joint pain, and limited mobility. Thyrozol was withdrawn.Symptoms disappeared after loxonin was given. Oral therapy was switched to propylthiouracil, no adverse reactions. Conclusion Antithyroid arthritis syndrome can occur when thyrozol therapy for hyperthyroidism. Prompt withdrawal of the antithyroid drug is necessary. 【Key words 】 Methimazole; Antithyroid agents; Arthritis syndrome 甲状腺功能亢进（hyperthyroidism ）的治疗方 病历资料 法有抗甲状腺药物治疗（antithyroid drug，ATD ）、