首发精神分裂症未经治疗时间与临床疗效间关系：4年随访研究.pdfVIP

• 42 • Shanghai Archives of Psychiatry, 2014, Vol. 26, No. 1 •Original Article• Duration of untreated psychosis and clinical outcomes of first- episode schizophrenia: a 4-year follow-up study Hongyun QIN*, Jie ZHANG, Zhenping WANG, Haiying MIN, Caiying YAN, Fuzhen CHEN, Weizhong FU, Ming ZHANG Background: The relationship between the duration of untreated psychosis and long-term clinical outcomes remains uncertain. Objective: Prospectively assess the relationship of the duration of untreated psychosis on clinical outcomes in a sample of individuals with first-onset schizophrenia treated at the Pudong Mental Health Center from January 2007 to December 2008. Methods: Information about general health, psychotic symptoms and social functioning were collected using the Brief Psychiatric Rating Scale (BPRS), Treatment Emergent Symptom Scale (TESS), Morningside Rehabilitation Status Scale (MRSS), and Social Disability Screening Schedule (SDSS) at baseline and in June 2010 and June 2012. Results: The 43 individuals with first-episode schizophrenia participating in the study were divided into short (≤24 weeks) and long (24weeks) duration of untreated psychosis (DUP) groups. The mean (sd) duration of follow-up was 1197 (401) days in the short DUP group and 1412 (306) days in the long DUP group ( =9.98, t p=0.055). Despite less prominent psychotic symptoms at the time of first diagnosis among patients who had a long DUP compared to those with a short DUP (BPRS mean scores, 42.5 [8.4] v. 50.0 [10.6], =2.42, =0.0210)