普罗布考联合辛伐他汀对急性冠脉综合征患者内皮功能的影响.pdfVIP

天津医药圆园10 年5 月第38 卷第5 期 395 普罗布考联合辛伐他汀对急性冠脉 综合征患者内皮功能的影响 张 寰 刘 勇 李焕明 李永辉 摘要 目的：探讨普罗布考和辛伐他汀早期联合应用对急性冠状动脉综合征（ACS ）内皮功能的影响。方法：将 ACS 患者随机分为单服辛伐他汀组（A 组）以及辛伐他汀联合普罗布考组（B 组），观察外周血氧化低密度脂蛋白（ox- LDL）和一氧化氮（NO）水平，应用高频超声检测肱动脉内皮依赖血管舒张功能（FMD ），用药治疗3 个月，比较治疗前 后上述指标的变化。结果: 2 组治疗前后ox-LDL 下降的幅度，A 组（125.0依22.3）mg/L 低于B 组（201.5依22.3 ）mg/L ，差异 有统计 意义（t = 30援远愿员，孕约 0.001）。2 组治疗后NO 升高的幅度，A 组（7.22依2.85）滋mol/L 低于B 组（0.81依3.21）滋mol/L， 差异有统计 意义（t = 员苑援猿源园 ，孕约 园援园员）。组治疗前后云MD 的差值比较，差异有统计学意义（P 约 0.05 ）。结论：辛伐他 汀合用抗氧化治疗能进一步改善ACS 患者的内皮功能。 关键词 急性病 药物疗法, 联合 内皮 降血脂药 急性冠状动脉综合征 病例对照研究 Effect of Probucol Combined with Simvastatin on Endothelial Function in Patients with Acute Coronary Syndrome ZHANG Huan, LIU Yong, LI Huanming, LI Yonghui De partment of Cardiology, Fourth Central Hospital of Tianj in, Tianj in 300140, China Abstract Obj ective: To investigate the effect of probucol combined with simvastatin on endothelial function in patients with acute coronary syndrome (ACS). Methods: A total of 60 ACS patients were randomly divided into two groups. Patients re鄄 ceived standard therapy plus simvastatin were group A (n=30), and standard therapy plus probucol combined with simvastatin were group B (n =30). The values of plasma oxidized low -density lipoprotein (ox -LDL) and nitric oxide (NO) were measured. The brachial arterial hyperemia-induced flow mediated dilation (FMD) mediated vasodilatations were measured by high reso鄄 lution ultrasound. These variables were analyzed before and after 3 months. Results: The level of plasma ox -LDL was signifi鄄 cantly lower before and after the treatment in group A than that in group B (P 约 0.001). The level of plas