BMSCs 在急性肺损伤中的研究进展.pdfVIP

198 Chinese Journal of Reparative and Reconstructive Surgery, February 2011, Vol. 25, No.2 · · BMSCs 在急性肺损伤中的研究进展 1 2 朱峰 郭光华 【摘  要】    目的 对BMSCs 在急性肺损伤（acute lung injury，ALI ）中的基础研究、临床进展及其机制进行综 述。  方法 查阅近年有关BMSCs 在ALI 中的基础研究及临床相关文献并进行综述。  结果 BMSCs 能主动归巢至 肺损伤部位并通过分化参与组织修复，同时BMSCs 能调节和平衡ALI 时局部和全身炎性反应和免疫紊乱。目前BMSCs 对ALI 抗炎- 免疫调节以及组织修复的机制尚不清楚。  结论 具有主动归巢、分化以及抗炎- 免疫调节效应的BMSCs 对ALI 具有全面的生物学效应，有望应用于临床，也为ALI 的基因- 干细胞治疗奠定了基础。 【关键词】 BMSCs 急性肺损伤 炎性反应 修复 RESEARCH PROGRESS OF BONE MARROW MESENCHYMAL STEM CELLS IN ACUTE LUNG INJURY/ZHU 1 2 1 2 Feng , GUO Guanghua . Department of Critical Care Medicine, Department of Burn, the First Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, P.R.China. Corresponding author: ZHU Feng, E-mail:139.com 【Abstract 】 Objective To review the basic research, the cl inical progress, and the mechanism of bone marrow mesenchymal stem cells (BMSCs) in acute lung injury (ALI). Methods The l iterature concerning the basic and cl inical researches of BMSCs in ALI was reviewed. Results BMSCs can take the initiative to “homing ” the site of lung injury and take partici pate in repair by means of differentiation, meanwhile BMSCs could regulate and balance local and systematic inflammatory response and immune disorders in ALI. Currently, the mechanism of BMSCs on anti-inflammation and immune regulation in ALI is not clear. Conclusion BMSCs have comprehensive biological effect on ALI, providing a potential clinical treatment and also laying the foundation for gene therapy and stem cell therapy of ALI in the future. 【Key words 】    Bone marrow mesenchymal stem