156例癫癎患者治疗药物浓度与不良反应监测.pdfVIP

·1384 · Herald of Medicine Vol郾29 No郾10 October2010 ·药物不良反应 · 156例癫患者治疗药物浓度与不良反应监测* 1 2 1 1 1 王锦秋 ,王摇 民 ,丰艳梅 ,蔡摇 艳 ,张抗怀 (1.西安交通大学医学院第二附属医院药剂科,710004;2.西安交通大学药业集团,710061) [摘摇 要]摇 目的摇 分析抗癫药物治疗过程中不良反应与血药浓度间的关系,探讨其安全使用问题。 方法摇 对 156例发现不良反应的病例进行治疗药物监测,并对结果进行评估分析。 结果摇 肝功能异常者53例,体质量增加者74 例,记忆力降低、学习能力减退12例,精神萎靡、乏力、嗜睡者5例,全身大面积皮疹3例(均服用卡马西平),全身不自主 抽搐1例,脱发2例,凝血障碍导致鼻出血3例,牙龈增生1例,中毒2例。 结论摇 癫患者治疗过程中有必要加强血药 浓度与不良反应的监测,保证用药安全。 [关键词]摇 抗癫药物;不良反应监测;药物监测;游离药物监测 [中图分类号]摇 R971.6摇 摇 摇 [文献标识码]摇 A摇 摇 摇 [文章编号]摇 1004-0781(2010)10-1384-03 Monitoring for Drug Concentration and Adverse Reaction in 156 Cases of Patients of Epilepsy 1 2 1 1 1 WANGJin鄄qiu ,WANGMin ,FENGYan鄄mei ,CAIYan ,ZHANGKang鄄huai (1. Departmentof Pharmacy, the Second Hospital Affiliated with Medical College,Xian Jiaotong University,Xian 710004, China;2. Pharmaceutical Group,Xian Jiaotong University,Xian710061,China) ABSTRACT摇 Objective摇 To analyze the relationship of adverse reaction and serum concentration of anti鄄epileptic drugs and to investigatethesafetyuseofthem. 摇 Methods摇 Drugmonitoringwascarriedouton156 casesofpatientshadadversedrug reactions,and the resultswere assessed. 摇 Results摇 53 cases showed abnormal liver function after treatment;74 cases gained body weight;12 cases showed memory andlearning ability decrease;5 casesinlow spirits,debility andlethargy;3 caseshad a large areaskinrash all overthebody;1showedthewholebody involuntary convulsion;2 alopecie;3 noseblood;1casegingiva hyperphasia and 2 toxication. 摇 Conclusion摇 During treatment for epilepsia, drug concentration monitoring should be accompaniedwith drug adverse reaction management to ensure the safety of patients. KE