妊娠高血压综合征病人瘦素水平与糖代谢的关系_医学论文.docVIP

妊娠高血压综合征病人瘦素水平与糖代谢的关系_医学论文 妊娠高血压综合征病人瘦素水平与糖代谢的关系_医学论文 【关键词】 妊娠并发症 　　［摘要］目的 探讨血清瘦素水平与妊娠高血压综合征（妊高征）病人糖代谢的关系。方法 对46例妊高征病人（妊高征组）及40例正常妊娠妇女（对照组）血清瘦素（LP）、空腹血糖（FBG）、空腹胰岛素（FINS）水平进行了检测，并对胰岛素抵抗指数（HOMA-IR）及胰岛素分泌指数（HOMA-IS）进行了分析比较。结果 妊高征组血清瘦素水平明显高于对照组（ t=8.100，P lt0.01）中、重度妊高征组瘦素水平明显高于轻度妊高征组（ F=8.312，q= 3.82、 4.37，P lt0.05）。妊高征组FINS水平、HOMA-IR及HOMA-IS与对照组比较明显升高（ t=3.242～7.588，P lt0.01）。各组间FBG水平比较差异无显著意义（ F=2.013，P gt0.05）。妊高征病人血清瘦素水平与FINS、 HOMA- IR、 HOMA- IS呈明显正相关（ r=0.542～0.583，P lt0.01）。结论 妊高征病人存在胰岛素抵抗及高胰岛素分泌，与血清瘦素水平升高密切相关。 　　［关键词］ 妊娠并发症，心血管高血压瘦素胰岛素血糖 　　 　　［ABSTRACT］ObjectiveTo investigate the relationship between the serum leptin levels and carbohydrate metabolism in pa-tients with pregnancy-induced hypertension （PIH）. MethodsSerum leptin levels were measured by radio immunoassay in 46 pa-tients with PIH （PIH group） and 40 normal pregnant women （control group）. Fasting serum insulin （FINS） and fasting blood glu-cose （FBG） levels were determined， respectively. Insulin resistance index （HOMA-IR） and β-cell function index （HOMA-IS） were analyzed. ResultsSerum leptin levels in PIH women were significantly higher than those in normal pregnancy （ t=8.100， P lt0.01）. Serum leptin levels in moderate PIH and severe PIH were higher than those in mild PIH women （ F=8.312q=3.82，4.37P lt0.05）. The levels of FINS， HOMA-IR and HOMA-IS in PIH group were significantly higher than those in normal pregnancy group （ t=3.242-7.588，P lt0.01）. Serum glucose levels had no significant difference between different groups （ F=2.013， P gt0.05）. The levels of leptin in PIH were correlated to the levels of FINS， HOMA-IR and HOMA-IS （ r=0.542-0.583，P lt0.01）. ConclusionBoth insulin secretion and insulin resistance are elevated in PIH， and correlate to the increased serum levels of leptin. 　　［KEY WORDS］pregnancy complication， cardiovascular hypertension leptin insulin blood glucose 　　妊娠高血压综合征（妊高征）是产科常见并发症之一，近年来的研究表明，妊高征病人普遍存在胰岛素抵抗，并认为胰岛素抵抗可能是妊高征发病原因之一［1］。瘦素作为肥胖基因的产物，在机体的能量代谢、脂肪沉积的调节中起重要作用［2］。本研究旨在探讨妊